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Targeting cancer metabolism to develop human lactate dehydrogenase (hLDH)5 inhibitors

Shao-Lin Zhang1, Yun He1, Kin Yip Tam2

  • 1Chongqing Key Laboratory of Natural Product Synthesis and Drug Research, School of Pharmaceutical Sciences, Chongqing University, 55 Daxuecheng South Road, Shapingba, Chongqing 401331, PR China.

Drug Discovery Today
|May 12, 2018
PubMed

Insights

Cancer cells rely on glycolysis, a metabolic pathway promoted by human lactate dehydrogenase (hLDH)5. Inhibiting hLDH5 offers a promising strategy for developing novel anticancer therapeutics targeting tumor metabolism.

Area of Science:

  • Biochemistry
  • Oncology
  • Metabolic pathways

Background:

  • Cancer cells exhibit altered glucose metabolism, shifting from oxidative phosphorylation to glycolysis.
  • This metabolic reprogramming supports tumor survival and proliferation.
  • Human lactate dehydrogenase (hLDH)5 is overexpressed in tumors and promotes glycolysis.

Purpose of the Study:

  • To review the role of hLDH5 in cancer metabolism.
  • To discuss small molecules targeting hLDH5 based on their binding modes.
  • To propose future directions for hLDH5 inhibitor development.

Main Methods:

  • Literature review of hLDH5's role in cancer.
  • Analysis of small molecule inhibitors and their binding interactions with hLDH5.
  • Exploration of potential therapeutic strategies.

Main Results:

  • hLDH5 is a key enzyme in cancer glycolysis.
  • Various small molecules targeting hLDH5 have been reported.
  • Understanding binding modes is crucial for inhibitor design.

Conclusions:

  • Targeting hLDH5 represents a viable strategy for anticancer drug development.
  • Further research into hLDH5 inhibitors could lead to effective cancer therapeutics.
  • hLDH5 is a significant target for modulating cancer metabolism.

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