Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Suppressor T cell function in undifferentiated collagenoses].

H Becker1, E Würden, K Helmke

  • 1III. Medizinische Klinik u. Poliklinik, Justus-Liebig-Universität Giessen.

Zeitschrift Fur Rheumatologie
|May 1, 1988
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Prognostic factors in the management of blunt hepatic injury.

Annali italiani di chirurgia·1992
Same author

Managerial issues associated with program evaluation in schools of nursing.

The Journal of nursing education·1992
Same author

Are CAT-scans necessary for preoperative localization of insulinomas?

The European journal of medicine·1992
Same author

[Liver function tests in a clinical comparison].

Zeitschrift fur Gastroenterologie·1992
Same author

Down syndrome complicated by brain tumors: case report and review of the literature.

Brain & development·1992
Same author

Capsulectomy--medically or legally indicated?

Plastic and reconstructive surgery·1992
Same journal

[Prevention strategies in rheumatoid arthritis : From primary prevention to targeted drug interception].

Zeitschrift fur Rheumatologie·2026
Same journal

Methodological concerns and data discrepancies in the indirect treatment comparison of belimumab and anifrolumab.

Zeitschrift fur Rheumatologie·2026
Same journal

Evaluating the comparative efficacy of belimumab vs. anifrolumab in systemic lupus erythematosus: a response.

Zeitschrift fur Rheumatologie·2026
Same journal

[Update: DMARDs for MGUS].

Zeitschrift fur Rheumatologie·2026
Same journal

[A potpourri of diagnoses-Unusual manifestations of a chronic inflammatory bowel disease : Case report].

Zeitschrift fur Rheumatologie·2026
Same journal

[Not measurable but immeasurably important : Fever-The leading symptom of ancient medical theory].

Zeitschrift fur Rheumatologie·2026
See all related articles

Early cellular defects in connective tissue diseases were studied by examining suppressor T-cell function. Patients with undifferentiated connective tissue syndromes showed reduced T8(CD8)-positive cell activity in suppressing IgM, but not IgG, secretion.

Area of Science:

  • Immunology
  • Cellular Biology
  • Rheumatology

Context:

  • Connective tissue diseases (CTDs) encompass a range of autoimmune disorders affecting connective tissues.
  • Early detection of cellular defects is crucial for understanding disease pathogenesis.
  • Undifferentiated connective tissue syndromes (UCTSS) represent an early stage in the spectrum of CTDs.

Purpose:

  • To investigate the function of suppressor T-cells (T8/CD8-positive cells) in patients with UCTSS.
  • To determine if specific immune responses, namely IgG and IgM secretion, are differentially affected by suppressor T-cell activity in UCTSS.
  • To identify potential early cellular defects in the immune system associated with CTDs.

Summary:

  • The study assessed the suppressor T-cell capacity to inhibit pokeweed mitogen-induced IgG and IgM secretion in 14 UCTSS patients.

Related Experiment Videos

  • Results indicated a significant reduction in the ability of T8(CD8)-positive cells to suppress IgM secretion compared to healthy controls.
  • Suppression of IgG secretion by T8(CD8)-positive cells remained unaffected in UCTSS patients.

    • Impact:

    • This research highlights a specific immune dysregulation (impaired IgM suppression) in early connective tissue disease.
    • Findings suggest that T8(CD8)-positive cell function may serve as a biomarker for early-stage CTDs.
    • Understanding these cellular defects can inform the development of targeted therapies for connective tissue diseases.