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Transaxillary First Rib Resection for Treatment of the Thoracic Outlet Syndrome
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Sarcopenia in Resected NSCLC: Effect on Postoperative Outcomes
Ryota Nakamura1, Yoshihisa Inage1, Rika Tobita1
1Department of Surgery, National Hospital Organization Mito Medical Center, Ibaraki, Japan.
Summary
Sarcopenia, or skeletal muscle depletion, is common in non-small cell lung cancer (NSCLC) patients undergoing surgery. This condition is an independent predictor of poor prognosis and increased complications after lung cancer resection.
Area of Science:
- Oncology
- Radiology
- Geriatrics
Background:
- Sarcopenia is an emerging risk factor for adverse outcomes in cancer patients.
- The prognostic value of sarcopenia in non-small cell lung cancer (NSCLC) patients post-pulmonary resection requires further investigation.
Purpose of the Study:
- To evaluate the impact of sarcopenia on prognosis and postoperative complications in patients undergoing surgical resection for NSCLC.
Main Methods:
- Retrospective analysis of 328 NSCLC patients who underwent curative resection.
- Preoperative CT scans assessed psoas muscle mass index (PMI) at the third lumbar vertebra.
- Sarcopenia defined by specific PMI cutoff values for males (6.36 cm²/m²) and females (3.92 cm²/m²).
Main Results:
- Sarcopenia was present in 55.8% of patients and associated with older age, male sex, smoking, lower BMI, and major postoperative complications.
- Five-year survival rates were 61% for sarcopenic patients versus 91% for non-sarcopenic patients.
- Multivariate analysis identified sarcopenia as an independent unfavorable prognostic factor (p=0.019).
Conclusions:
- Preoperative CT-assessed sarcopenia can predict major postoperative complications and prognosis in resected NSCLC patients.
- Findings offer valuable insights for preoperative management strategies in lung cancer surgery.
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