Related Experiment Videos
Gene dosage effect in cells with monosomy of chromosome 22 derived from human meningiomas
R Casalone1, A Minelli, G Butti
1Biologia generale e Genetica Medica, Università di Pavia, Italy.
Acta Neurochirurgica. Supplementum
|January 1, 1988
Abstract:
Enzymatic determinations of four enzymes, Arylsulphatase A (ARSA), alpha-iduronidase (IDUA), beta-galactosidase (GLB) and hexosaminidase were performed in 19 cases of meningioma. Gene dosage effect was demonstrated for ARSA and IDUA; preliminary evidence for mapping a "protective protein" of GLB in the region 22pter----q11 was also obtained.