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Updated: Feb 10, 2026

Gamete Collection and In Vitro Fertilization of Astyanax mexicanus
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Gamete intrafallopian transfer: A preliminary experience.

I N Hinduja1, A K Gupta1, J P Shah1

  • 1Department of Obstetrics and Gynaecology, Seth G.S. Medical College and K.E.M. Hospital, Parel, Bombay 400012, India.

The National Medical Journal of India
|May 13, 2018
PubMed
Summary
This summary is machine-generated.

Gamete intrafallopian transfer (GIFT) was adapted for non-tubal infertility using a novel storage box, overcoming logistical challenges. This technique successfully resulted in pregnancies and live births, demonstrating its applicability in India.

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Area of Science:

  • Reproductive Medicine
  • Infertility Treatment
  • Assisted Reproductive Technologies

Background:

  • Gamete intrafallopian transfer (GIFT) is an assisted reproductive technology for non-tubal infertility.
  • A key limitation of GIFT is the short 2-5 minute viability window for gametes outside the body.
  • Hospital infrastructure, specifically the distance between operating theatres and laboratories, hindered GIFT implementation.

Purpose of the Study:

  • To address the logistical challenges of GIFT implementation.
  • To develop a method for preserving gamete viability during transfer.
  • To assess the efficacy of a modified GIFT technique in achieving pregnancies.

Main Methods:

  • A specialized storage box was designed to maintain gamete viability.
  • Standard GIFT procedures were employed using gametes retrieved from the storage box.
  • The technique was applied to infertile women undergoing assisted reproduction.

Main Results:

  • The modified GIFT technique was utilized in 39 women across 41 treatment cycles.
  • Oocyte retrieval was performed in 39 women.
  • Five pregnancies were achieved, with four resulting in full-term live births and one abortion.

Conclusions:

  • The developed gamete storage solution overcomes critical time constraints in GIFT.
  • The modified GIFT technique is a viable and successful option for treating non-tubal infertility.
  • This adaptation of GIFT is suitable for implementation in India.