Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Tumor Immunotherapy01:27

Tumor Immunotherapy

2.0K
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
2.0K
Passive Filters01:27

Passive Filters

1.0K
Passive filters are utilized to shape the frequency spectrum of signals across a diverse array of applications. These filters, using only passive elements like resistors (R), inductors (L), and capacitors (C), are capable of selectively allowing or blocking certain frequency ranges without the need for external power sources.
Low-Pass Filters
Low-pass filters are designed to transmit signals with frequencies lower than the cutoff frequency, ωc, and attenuate those above it. The cutoff...
1.0K
Psychodynamic Perspectives on Personality01:27

Psychodynamic Perspectives on Personality

1.6K
The psychodynamic perspective in psychology asserts that most personality functions operate unconsciously, outside of awareness. This means that the motives and emotions driving behavior often remain hidden, automatically buried in the unconscious mind as a defense mechanism to shield us from psychological distress. According to this theory, the unconscious mind contains thoughts, memories, and emotions that are too disturbing to face directly.
Psychodynamic theorists argue that unconscious...
1.6K
Active versus Passive Immunity01:31

Active versus Passive Immunity

11.0K
Immunity, along with the ability to limit pathogen growth to prevent significant body tissue damage, can be gained either by (1) actively developing an immune response within the individual after exposure to a pathogen or after getting vaccinated or (2) passively transferring immune components from an immune individual to one who is nonimmune. Both these forms of immunity can be found naturally and in medical practices.
Active Immunity
Active immunity refers to the resistance one develops...
11.0K
Social Cognitive Perspective on Personality01:30

Social Cognitive Perspective on Personality

1.0K
Social cognitive perspectives on personality emphasize the importance of conscious awareness, beliefs, expectations, and goals in shaping behavior. These perspectives incorporate behaviorist principles, such as learning through reinforcement and conditioning, but extend beyond them by highlighting human reasoning and planning. Unlike traditional behaviorist views, social cognitive theory focuses on how individuals reflect on their past experiences and plan for future outcomes by considering...
1.0K
Criticisms of the Evolutionary Perspective01:23

Criticisms of the Evolutionary Perspective

377
In a study where individuals posing as strangers offered compliments and proposed casual sex to students, the responses differed significantly based on gender. Not a single woman accepted the proposal, while 70% of the men agreed. This outcome provides a useful scenario to explore through the lens of evolutionary psychology and social learning theory, highlighting the diverse perspectives on human sexual behaviors.
Evolutionary psychology provides one explanation for these findings, suggesting...
377

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Immunotherapy with B28, an antibody to Aβ oligomers, potently decreases amyloid plaques, microgliosis, and memory decline in APP knock-in mice.

Cell reports·2026
Same author

Early binding of anti-amyloid antibodies to CAA drives complement activation, inflammation and ARIA in mice.

Molecular neurodegeneration·2026
Same author

Ex vivo comparison of ACU193 and lecanemab reveals binding differences in mouse brain.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same author

Amyloid-related imaging abnormalities (ARIA) in anti-amyloid therapies for Alzheimer's disease: An update from the Alzheimer's Association ARIA workgroup.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same author

C3 lowering in adult APP KI mice rescues synapses and spares cognitive decline.

Molecular neurodegeneration advances·2026
Same author

Anti-amyloid antibody equilibrium binding to Aβ aggregates from human Alzheimer's disease brain.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026

Related Experiment Video

Updated: Feb 10, 2026

Perspectives on Neuroscience
26:41

Perspectives on Neuroscience

Published on: July 31, 2007

5.3K

Passive Aβ Immunotherapy: Current Achievements and Future Perspectives.

Stephan Schilling1, Jens-Ulrich Rahfeld2, Inge Lues3

  • 1Fraunhofer Institute for Cell Therapy and Immunology, Department for Drug Design and Target Validation, 06120 Halle (Saale), Germany. stephan.schilling@izi.fraunhofer.de.

Molecules (Basel, Switzerland)
|May 13, 2018
PubMed
Summary

Passive immunotherapy using amyloid β (Aβ) antibodies shows promise for neurodegenerative diseases. Challenges include side effects like amyloid-related imaging abnormalities (ARIAs), with new strategies focusing on modified Aβ peptides.

Keywords:
amyloid-βdrug developmentmonoclonal antibodiesposttranslational modifications

More Related Videos

Manufacturing Chimeric Antigen Receptor CAR T Cells for Adoptive Immunotherapy
06:51

Manufacturing Chimeric Antigen Receptor CAR T Cells for Adoptive Immunotherapy

Published on: December 17, 2019

16.0K
Sublingual Immunotherapy as an Alternative to Induce Protection Against Acute Respiratory Infections
16:56

Sublingual Immunotherapy as an Alternative to Induce Protection Against Acute Respiratory Infections

Published on: August 30, 2014

17.6K

Related Experiment Videos

Last Updated: Feb 10, 2026

Perspectives on Neuroscience
26:41

Perspectives on Neuroscience

Published on: July 31, 2007

5.3K
Manufacturing Chimeric Antigen Receptor CAR T Cells for Adoptive Immunotherapy
06:51

Manufacturing Chimeric Antigen Receptor CAR T Cells for Adoptive Immunotherapy

Published on: December 17, 2019

16.0K
Sublingual Immunotherapy as an Alternative to Induce Protection Against Acute Respiratory Infections
16:56

Sublingual Immunotherapy as an Alternative to Induce Protection Against Acute Respiratory Infections

Published on: August 30, 2014

17.6K

Area of Science:

  • Neuroscience
  • Immunology
  • Pharmacology

Background:

  • Neurodegenerative disorders are linked to amyloid peptide misfolding and deposition.
  • Passive immunotherapy, particularly using antibodies targeting amyloid β (Aβ), is a key strategy.
  • Current treatments focus on Aβ antibodies, but face challenges in clinical trials.

Purpose of the Study:

  • To review the current status of Aβ antibodies in clinical development.
  • To discuss challenges encountered during clinical trials of these new biological entities (NBEs).
  • To explore strategies for overcoming common side effects, such as amyloid-related imaging abnormalities (ARIAs).

Main Methods:

  • Literature review of clinical trials and research on Aβ antibodies.
  • Analysis of characteristics, efficacy, and safety profiles of Aβ antibodies.
  • Examination of emerging therapeutic approaches, including antibodies targeting modified Aβ peptides.

Main Results:

  • Aβ antibodies are central to passive immunotherapy for Alzheimer's disease and related disorders.
  • Clinical trials reveal challenges, including the occurrence of ARIAs.
  • Targeting post-translationally modified Aβ variants presents a novel therapeutic avenue.

Conclusions:

  • Passive immunotherapy with Aβ antibodies holds significant therapeutic potential.
  • Addressing side effects like ARIAs is crucial for successful clinical application.
  • Targeting modified Aβ peptides offers a promising future direction for developing advanced antibody therapies.