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lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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PIWI-interacting RNAs, or piRNAs, are the most abundant short non-coding RNAs. More than 20,000 genes have been found in humans that code for piRNAs while only 2000 genes have been found for miRNAs. piRNAs can act at the transcriptional and post-transcriptional levels and have a vital role in silencing transposable elements present in germ cells. They are also involved in epigenetic silencing and activation. Previously, they were thought to function only in germ cells but new evidence suggests...
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The Nursing Code of Ethics sets the ethical benchmark for the profession, and guides nurses in ethical analysis and decision making at the societal, organizational, and clinical levels. The code encompasses showing compassion and respect for the patient, their families, and communities in all circumstances while committing to providing patient-centered care. In addition, the code states that nurses must advocate for the patient by defending a cause or recommendation to protect their rights,...
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Long Non-Coding RNAs in Multifactorial Diseases: Another Layer of Complexity.

Gabriel A Cipolla1, Jaqueline C de Oliveira2, Amanda Salviano-Silva3

  • 1Department of Genetics, Federal University of Parana, Curitiba 81531-980, Brazil. gabriel.cipolla@ufpr.br.

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Long non-coding RNAs (lncRNAs) are increasingly implicated in multifactorial diseases like cancer and heart conditions. This review highlights their diagnostic and therapeutic potential in complex human pathologies.

Keywords:
biomarkerscomplex diseaseslncRNAs

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Area of Science:

  • Genomics
  • Molecular Biology
  • Pathology

Background:

  • Multifactorial diseases result from genetic and environmental interactions.
  • Non-coding RNAs (ncRNAs), particularly long non-coding RNAs (lncRNAs), are transcribed from most of the human genome and are deregulated in disease.
  • lncRNAs show promise for clinical applications due to their specificity and differential expression.

Purpose of the Study:

  • To review the involvement of specific lncRNAs in common multifactorial diseases.
  • To focus on lncRNAs with published functional data relevant to human pathologies.
  • To explore the potential of lncRNAs in risk assessment and prognosis.

Main Methods:

  • Literature review of scientific publications.
  • Analysis of RNA sequencing data.
  • Focus on studies with functional data for lncRNAs in disease.

Main Results:

  • lncRNAs are significantly deregulated in various multifactorial diseases.
  • Specific lncRNAs have demonstrated roles in the pathogenesis of conditions like cancer and cardiovascular diseases.
  • lncRNAs exhibit potential as biomarkers for diagnosis and prognosis.

Conclusions:

  • lncRNAs are crucial players in multifactorial diseases.
  • Further research into lncRNAs can enhance understanding, risk assessment, and treatment strategies.
  • lncRNAs hold significant promise for clinical translation in managing complex human diseases.