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Mechanisms Underlying Gut Hormone Secretion Using the Isolated Perfused Rat Small Intestine
Published on: February 26, 2019
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Intestinal Absorption of Fructose
Ronaldo P Ferraris1, Jun-Yong Choe2, Chirag R Patel3
1Department of Pharmacology, Physiology and Neuroscience, New Jersey Medical School, Rutgers University, Newark, New Jersey 07946, USA;
Annual Review of Nutrition
|May 13, 2018
Summary
Dietary fructose absorption in the intestine is crucial for understanding its health impacts. This review details fructose transport mechanisms and its role in metabolic diseases and gut health.
Area of Science:
- Gastroenterology and Metabolism
- Molecular Biology
- Nutritional Science
Background:
- Fructose is a significant dietary component linked to metabolic diseases and cancers.
- Intestinal fructose absorption is a key step in its systemic processing.
- Understanding fructose transport is vital for public health.
Purpose of the Study:
- To review current knowledge on intestinal fructose absorption.
- To examine the roles of GLUT5 and GLUT2 transporters in fructose uptake.
- To explore the physiological and pathological implications of dietary fructose.
Main Methods:
- Literature review of studies on fructose metabolism and transport.
- Analysis of research on transporter structure, ligand binding, and activity.
- Examination of data on fructose sensing, enzyme regulation, and interactions with minerals/electrolytes.
Main Results:
- Intestinal fructose absorption involves apical GLUT5 and basolateral GLUT2.
- The role of apical GLUT2 in fructose absorption remains a subject of debate.
- Dietary fructose influences transporter expression, enzyme activity, and nutrient transport.
Conclusions:
- Dietary fructose metabolism is complex, involving multiple transporters and cellular processes.
- Fructose absorption impacts systemic glucose and lipid metabolism.
- Further research is needed to clarify fructose's contribution to gastrointestinal diseases and the gut microbiome.
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