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On the preparation of dihematoporphyrin ether-free hematoporphyrin derivative
H Häberlein1, P Both, M O Doss
1Abteilung für Klinische Biochemie im Fachbereich Humanmedizin der Philipps Universität Marburg.
Abstract:
A dihematoporphyrin ether-free hematoporphyrin derivative has been prepared by a base-catalysed dehydration of hematoporphyrin with sodium hydroxide. The identification was performed by HPLC and mass spectroscopy (FD-MS). The reaction of hematoporphyrin with 1 M sodium hydroxide for 24 h yields more than 90% of the monomeric porphyrins.