Related Experiment Video
Updated: Feb 10, 2026
08:31
Three-dimensional Alginate-bead Culture of Human Pituitary Adenoma Cells
Published on: February 18, 2016
10.5K
Hepatic Adenomas: Classification, Controversies, and Consensus.
1Department of Laboratory Medicine and Pathology, 100 1st SE, Rochester, MN 55905, USA.
Surgical Pathology Clinics
|May 13, 2018
Summary
Recent advances in pathology enhance understanding of hepatocellular adenomas. A histology-based classification aids in identifying high-risk tumors, though controversies persist regarding less common types and clinical integration.
Area of Science:
- Hepatobiliary pathology
- Molecular diagnostics
- Oncology
Background:
- Hepatocellular adenomas (HCAs) are benign liver tumors with malignant transformation potential.
- Advances in molecular and anatomic pathology have refined HCA understanding.
- A histology-based classification system has emerged, improving risk stratification.
Purpose of the Study:
- To review the current classification of hepatocellular adenomas.
- To discuss the rationale, consensus, and controversies surrounding HCA subtyping.
- To explore the integration of HCA subtyping into clinical practice.
Main Methods:
- Review of current literature on hepatocellular adenoma classification.
- Analysis of consensus and areas of controversy in HCA subtyping.
- Discussion of clinical implications of HCA classification.
Main Results:
- A consensus exists on major hepatocellular adenoma subtypes based on histology.
- Controversies remain regarding the classification of less common HCA types.
- Challenges exist in integrating HCA subtyping into routine clinical care.
Conclusions:
- The current histology-based classification of hepatocellular adenomas is clinically relevant.
- Further consensus is needed for less common HCA subtypes and their clinical management.
- Optimizing the integration of HCA subtyping into clinical practice is crucial.
Related Concept Videos
01:22Force Classification
2.4K
Forces play a crucial role in the study of physics and engineering. They are essential in describing the motion, behavior, and equilibrium of objects in the physical world. Forces can be classified based on their origin, type, and direction of action.
Contact and non-contact forces are two of the most widely used categories of forces. As the name suggests, contact forces require physical contact between two objects to act upon each other. Examples of contact forces include frictional,...
Contact and non-contact forces are two of the most widely used categories of forces. As the name suggests, contact forces require physical contact between two objects to act upon each other. Examples of contact forces include frictional,...
2.4K
01:30Classification of Neurotransmitters
5.4K
Neurotransmitters play a crucial role in the communication between neurons in the autonomic nervous system. Neurons in the autonomic nervous system can be cholinergic or adrenergic depending on the neurotransmitters synthesized. Cholinergic neurons use acetylcholine as their primary neurotransmitter. This includes all the preganglionic fibers of the sympathetic and pre- and postganglionic fibers of the parasympathetic nervous systems. In addition, neurons of the somatic nervous system also use...
5.4K
01:30Classification of Leukocytes
6.1K
Leukocytes are classified into two groups based on the presence or absence of cytoplasmic granules. Granular leukocytes, which contain granules, belong to the myeloid lineage and are divided into three subtypes: neutrophils, eosinophils, and basophils. These cells are roughly spherical and characterized by the granules in their cytoplasm.
Neutrophils are the most abundant type of granular leukocytes, comprising 50-70% of all leukocytes. They feature small, evenly distributed granules and a...
Neutrophils are the most abundant type of granular leukocytes, comprising 50-70% of all leukocytes. They feature small, evenly distributed granules and a...
6.1K
01:17Classification of Illness
8.8K
The meaning of illness is individualized to each person who experiences an alteration in health. In contrast, disease is a medical term indicating a pathological change in the structure and function of the body or mind. It is a condition that has specific symptoms and boundaries.
An illness is a response to a disease in which the person's level of functioning is changed compared with a previous level. The general classification of illness includes acute and chronic.
Acute illness is severe...
An illness is a response to a disease in which the person's level of functioning is changed compared with a previous level. The general classification of illness includes acute and chronic.
Acute illness is severe...
8.8K
01:18Classification of Bones
10.1K
The bones of the human skeletal system are of varied shapes, sizes, and functions. They can be classified based on their shape and function into four major classes: long bones, short bones, flat bones, and irregular bones. Some classifications include a fifth type, the sesamoid bones, as a separate class, whereas others categorize them under short bones.
Long and Short Bones
The appendicular skeleton, particularly the upper and lower limbs, is primarily made of long and short bones. The...
Long and Short Bones
The appendicular skeleton, particularly the upper and lower limbs, is primarily made of long and short bones. The...
10.1K
01:08Effect of Hepatic Disease on Pharmacokinetics: Dose Adjustments Due to Hepatic Impairment
281
Hepatic impairment, characterized by decreased liver function, does not uniformly mandate adjustments in drug dosage. Whether dosage modifications are necessary depends on various factors related to the drug's metabolism and elimination pathways. If a drug is primarily excreted via the kidneys and bypasses significant hepatic processing, if it undergoes minimal metabolic transformation in the liver, or if it is volatile and primarily expelled through the lungs, dose adjustments may not be...
281