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Related Concept Videos

Nursing Diagnosis01:22

Nursing Diagnosis

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Following assessment, a nursing diagnosis is the next step in the nursing process. It begins after the nurse has collected and recorded the patient data. The purpose of diagnosing is to identify how the client responds to actual or potential health processes, identify factors that bestow or that cause health problems, the etiologies, and identify resources or strengths the individual, group, or community can draw on to prevent or resolve problems.
The nursing diagnosis focuses on evidence-based...
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Effect of Hepatic Disease on Pharmacokinetics: Dose Adjustments Due to Hepatic Impairment01:08

Effect of Hepatic Disease on Pharmacokinetics: Dose Adjustments Due to Hepatic Impairment

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Hepatic impairment, characterized by decreased liver function, does not uniformly mandate adjustments in drug dosage. Whether dosage modifications are necessary depends on various factors related to the drug's metabolism and elimination pathways. If a drug is primarily excreted via the kidneys and bypasses significant hepatic processing, if it undergoes minimal metabolic transformation in the liver, or if it is volatile and primarily expelled through the lungs, dose adjustments may not be...
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Hepatic Portal System01:21

Hepatic Portal System

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The hepatic portal system, a critical part of our circulatory framework, transports nutrient-laden, deoxygenated blood from the gastrointestinal tract and spleen to the liver. This ingenious system plays an indispensable role in maintaining our body's metabolic equilibrium.
At its core, the hepatic portal vein is the result of a confluence of the superior and inferior mesenteric veins along with the splenic vein. Each of these veins has a unique role. The superior mesenteric vein is...
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Formulating and Validating Nursing Diagnosis I01:26

Formulating and Validating Nursing Diagnosis I

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A nursing diagnosis is written when the nurse recognizes a cluster of essential patient data indicating health problems treated with independent nursing interventions. The standardized terminologies of a nursing diagnosis help nurses identify and treat patients' problems. Every electronic health record that uses nursing diagnosis must employ standard diagnostic terminology. Developing an efficient, individualized care plan begins with accurate nursing diagnoses.
There are thirteen domains...
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Documentation of Nursing Diagnosis01:10

Documentation of Nursing Diagnosis

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The nurse documents nursing diagnoses and enters them into the patient record. The identified patient's nursing diagnosis is either written out with a plan of care or entered into the electronic health record.
In some settings, data-driven computerized decision support systems are in place, allowing for more accurate nursing diagnoses. The database within one of these systems includes diagnostic labels defining characteristics, activities, and indicators for nursing. A nurse enters...
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Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow01:26

Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow

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Chronic liver disease significantly impacts drug metabolism due to alterations in hepatic blood flow and enzyme accessibility. This disruption affects the body's pharmacokinetics—the movement and processing of drugs within the system. Key enzymes crucial for metabolizing medications become less accessible, changing how drugs are processed and utilized. Furthermore, liver disease influences the synthesis of plasma proteins, such as albumin and globulins, which play critical roles in drug...
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Author Spotlight: Advancing VRL Diagnosis Using Cell-Free DNA Extraction from Vitreous Humor
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Hepatic Lymphoma Diagnosis.

Won-Tak Choi1, Ryan M Gill1

  • 1Department of Pathology, University of California at San Francisco, 505 Parnassus Avenue, M552, Box 0102, San Francisco, CA 94143, USA.

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|May 13, 2018
PubMed
Summary

Primary hepatic lymphoma (PHL) and other hematopoietic disorders can appear on liver biopsies. This review covers their features, differential diagnoses, and testing to aid hepatopathologists in accurate identification.

Keywords:
Aggressive NK-cell leukemiaB-lymphoblastic leukemia/lymphomaBurkitt lymphomaChronic lymphocytic leukemia/small lymphocytic lymphomaClassic Hodgkin lymphomaDiffuse large B-cell lymphomaFollicular lymphomaHairy cell leukemia

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Area of Science:

  • Hepatopathology
  • Hematologic Neoplasms
  • Liver Biopsy Analysis

Background:

  • Systemic hematopoietic disorders can manifest in the liver.
  • Primary hepatic lymphoma (PHL) is a rare hepatic neoplasm.
  • PHL can mimic other liver pathologies on imaging and biopsy.

Purpose of the Study:

  • To familiarize hepatopathologists with hematopoietic disorders in the liver.
  • To describe the diagnostic features of primary hepatic lymphoma.
  • To guide differential diagnosis and ancillary testing for liver hematopoietic neoplasms.

Main Methods:

  • Review of clinical, morphologic, and immunophenotypic features.
  • Discussion of differential diagnoses.
  • Recommendations for ancillary testing.

Main Results:

  • Hematopoietic neoplasms present diverse features on liver biopsy.
  • Primary hepatic lymphoma can mimic carcinoma or benign inflammatory conditions.
  • Accurate diagnosis requires careful evaluation of morphology and immunophenotype.

Conclusions:

  • Hepatopathologists need to recognize hematopoietic neoplasms in liver biopsies.
  • Distinguishing PHL from mimics is crucial for patient management.
  • Comprehensive evaluation including ancillary tests aids diagnosis.