Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Histone Variants at the Centromere02:30

Histone Variants at the Centromere

5.1K
Histone variants are the histone proteins with structural and sequence variations. These variants may be regarded as “mutant” forms that replace their canonical histone counterparts in the nucleosomes. Specific post-translational modifications on the histone variants enable further chromatin complexity and regulate tissue-specific gene expression. The most common histone variants are from histone H2A, H2B, and linker histone H1 families. However, several variants of histone H3...
5.1K
Common Ion Effect03:24

Common Ion Effect

47.0K
Compared with pure water, the solubility of an ionic compound is less in aqueous solutions containing a common ion (one also produced by dissolution of the ionic compound). This is an example of a phenomenon known as the common ion effect, which is a consequence of the law of mass action that may be explained using Le Châtelier’s principle. Consider the dissolution of silver iodide:
47.0K
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

10.0K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
10.0K
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

3.7K
3.7K
Nursing Code of Ethics01:29

Nursing Code of Ethics

4.6K
The Nursing Code of Ethics sets the ethical benchmark for the profession, and guides nurses in ethical analysis and decision making at the societal, organizational, and clinical levels. The code encompasses showing compassion and respect for the patient, their families, and communities in all circumstances while committing to providing patient-centered care. In addition, the code states that nurses must advocate for the patient by defending a cause or recommendation to protect their rights,...
4.6K
Conduct Disorder01:28

Conduct Disorder

600
Conduct disorder is a complex mental health diagnosis characterized by a repetitive and persistent pattern of behavior that violates societal norms, the rights of others, or age-appropriate rules. The diagnostic criteria for conduct disorder require the presence of at least three problematic behaviors within the past 12 months, with at least one occurring in the past six months. These behaviors are grouped into four categories: aggression toward people and animals; destruction of property;...
600

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Colocalization of eQTLs With Type 2 Diabetes and Glycemic Traits Using Whole-Genome Sequences in Diverse Populations From the NHLBI Trans-Omics in Precision Medicine (TOPMed) Program.

Diabetes·2026
Same author

Publisher Correction: Whole genome sequence analysis of pulmonary function and COPD in 44,287 multi-ancestry participants.

Genome biology·2026
Same author

Admixture-informed polygenic risk reporting using the ePRS framework.

Nature communications·2026
Same author

Estimating population structure using epigenome-wide methylation data.

Briefings in bioinformatics·2026
Same author

An integrated germline and somatic genomic model for coronary artery disease.

Nature communications·2026
Same author

Gene-by-Sleep Duration Interaction for Glycemic Traits in over 480,000 Individuals.

medRxiv : the preprint server for health sciences·2026

Related Experiment Video

Updated: Feb 10, 2026

Cardiac Pressure-Volume Loop Analysis Using Conductance Catheters in Mice
08:15

Cardiac Pressure-Volume Loop Analysis Using Conductance Catheters in Mice

Published on: September 17, 2015

20.0K

Common Coding Variants in SCN10A Are Associated With the Nav1.8 Late Current and Cardiac Conduction.

Vincenzo Macri1, Jennifer A Brody2, Dan E Arking3

  • 1Cardiovascular Research Center, Massachusetts General Hospital, Charlestown (V.M., W.J.H., R.W.M., S.A.L., E.V.D., S.L.P., C.N.-C., D.J.M., P.T.E.).

Circulation. Genomic and Precision Medicine
|May 13, 2018
PubMed
Summary
This summary is machine-generated.

Genetic variants in SCN10A influence cardiac conduction by affecting the late sodium current. This study identifies specific SCN10A variants associated with altered PR and QRS intervals, impacting heart rhythm.

Keywords:
Na+ channelsatrial fibrillationelectrocardiographygeneticshaplotypespopulation

More Related Videos

Screening for Functional Non-coding Genetic Variants Using Electrophoretic Mobility Shift Assay EMSA and DNA-affinity Precipitation Assay DAPA
11:35

Screening for Functional Non-coding Genetic Variants Using Electrophoretic Mobility Shift Assay EMSA and DNA-affinity Precipitation Assay DAPA

Published on: August 21, 2016

13.5K
A Strategy to Identify de Novo Mutations in Common Disorders such as Autism and Schizophrenia
05:51

A Strategy to Identify de Novo Mutations in Common Disorders such as Autism and Schizophrenia

Published on: June 15, 2011

26.5K

Related Experiment Videos

Last Updated: Feb 10, 2026

Cardiac Pressure-Volume Loop Analysis Using Conductance Catheters in Mice
08:15

Cardiac Pressure-Volume Loop Analysis Using Conductance Catheters in Mice

Published on: September 17, 2015

20.0K
Screening for Functional Non-coding Genetic Variants Using Electrophoretic Mobility Shift Assay EMSA and DNA-affinity Precipitation Assay DAPA
11:35

Screening for Functional Non-coding Genetic Variants Using Electrophoretic Mobility Shift Assay EMSA and DNA-affinity Precipitation Assay DAPA

Published on: August 21, 2016

13.5K
A Strategy to Identify de Novo Mutations in Common Disorders such as Autism and Schizophrenia
05:51

A Strategy to Identify de Novo Mutations in Common Disorders such as Autism and Schizophrenia

Published on: June 15, 2011

26.5K

Area of Science:

  • Cardiovascular Genetics
  • Molecular Cardiology
  • Electrophysiology

Background:

  • Genetic variants in the SCN5A/SCN10A locus are linked to PR and QRS interval variations.
  • SCN5A is a known cardiac sodium channel gene, but SCN10A's role in cardiac conduction requires further elucidation.

Purpose of the Study:

  • To identify SCN10A variants associated with cardiac conduction.
  • To investigate the biophysical effects of SCN10A variants on cardiac channel function.

Main Methods:

  • Sequencing of the SCN10A locus in European-ancestry individuals.
  • Replication in a larger cohort and association analysis with atrial tissue expression.
  • Cellular electrophysiology to assess channel function of identified variants.

Main Results:

  • Two intronic single nucleotide polymorphisms (SNPs) showed strong associations with PR and QRS intervals.
  • These SNPs were in high linkage disequilibrium with SCN10A missense variant rs6795970 (V1073A).
  • Four missense variants (I962V, P1045T, V1073A, L1092P) clustered in a specific protein region and formed haplotypes affecting the late sodium current.

Conclusions:

  • Genetic variation in SCN10A is associated with alterations in cardiac conduction.
  • The late sodium current is implicated in the functional effects of SCN10A variants on cardiac electrophysiology.