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Quality of Life (QoL) and the Factors Affecting it in Transfusion-dependent Thalassemic Children

Kapil Chordiya1, Vikash Katewa2, Pramod Sharma1

  • 1Department of Pediatrics, Dr. S. N. Medical College, Jodhpur, Rajasthan, India.

Indian Journal of Pediatrics
|May 13, 2018
PubMed

Insights

Higher age, frequent transfusions, and injectable chelation negatively impact quality of life (QoL) in children with transfusion-dependent thalassemia. Interventions should target these factors to improve QoL.

Area of Science:

  • Pediatrics
  • Hematology
  • Quality of Life Research

Background:

  • Thalassemia is a significant genetic blood disorder requiring lifelong treatment.
  • Transfusion-dependent thalassemia (TDT) necessitates regular blood transfusions and chelation therapy.
  • Understanding factors influencing Quality of Life (QoL) is crucial for comprehensive patient care.

Purpose of the Study:

  • To evaluate the Quality of Life (QoL) in transfusion-dependent thalassemic children.
  • To identify specific factors affecting QoL in this pediatric population.

Main Methods:

  • A study involving 93 transfusion-dependent thalassemic children aged 8-18 years.
  • Quality of Life assessed using the Pediatric Quality of Life (PedsQL) measurement model.
  • Data collected on age, transfusion frequency, chelation therapy, and other relevant factors.

Main Results:

  • School functioning had the lowest mean PedsQL score (57.4).
  • Younger children (8-12 years) reported higher PedsQL scores than older children (13-18 years).
  • Children with less frequent transfusions and those on combined chelation therapy showed better QoL.

Conclusions:

  • Higher age, increased transfusion frequency, and injectable chelation are associated with lower QoL in thalassemic children.
  • Targeted programs and interventions focusing on these domains are recommended to enhance QoL.
  • QoL was not significantly affected by gender, education, family history, ferritin levels, splenectomy, or consanguinity.
Abstract

Keywords:
PedsQLThalassemiaTransfusion-dependent

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