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Updated: Feb 10, 2026

Whole-cell Recordings of Light Evoked Excitatory Synaptic Currents in the Retinal Slice
Published on: July 2, 2008
In vivo super-resolution imaging of transient retinal phototropism evoked by oblique light stimulation
Yiming Lu1, Changgeng Liu1, Xincheng Yao1,2
1University of Illinois at Chicago, Department of Bioengineering, Chicago, Illinois, United States.
Abstract:
Rod-dominated transient retinal phototropism (TRP) has been observed in freshly isolated retinas, promising a noninvasive biomarker for objective assessment of retinal physiology. However, in vivo mapping of TRP is challenging due to its subcellular signal magnitude and fast time course. We report here a virtually structured detection-based super-resolution ophthalmoscope to achieve subcellular spatial resolution and millisecond temporal resolution for in vivo imaging of TRP. Spatiotemporal properties of in vivo TRP were characterized corresponding to variable light intensity stimuli, confirming that TRP is tightly correlated with early stages of phototransduction.
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