Correlation between duration of preoperative fasting and emergence delirium in pediatric patients undergoing

Puneet Khanna1, Kulbhushan Saini1, Renu Sinha1

  • 1Department of Anaesthesiology, Pain Medicine & Critical Care, All India Institute of Medical Sciences, New Delhi, India.

Insights

Longer preoperative fasting in children may increase the risk of postoperative emergence delirium. This study found a correlation between fasting duration and delirium scores in pediatric ophthalmic surgery patients.

Area of Science:

  • Pediatric Anesthesiology
  • Ophthalmology
  • Surgical Patient Care

Background:

  • Preoperative fasting in children can induce anxiety, potentially leading to postoperative emergence delirium.
  • Limited data exists on the correlation between preoperative fasting duration and emergence delirium in pediatric patients.

Purpose of the Study:

  • To investigate the relationship between the duration of preoperative fasting and the occurrence of emergence delirium in children undergoing ophthalmic examinations under anesthesia.

Main Methods:

  • A prospective observational study included 100 children (2-6 years, ASA I/II) undergoing ophthalmic examination under general anesthesia.
  • Preoperative fasting duration was recorded, and emergence delirium was assessed using the Pediatric Anesthesia Emergence Delirium (PAED) scale postoperatively.
  • No premedication was administered, but parental presence was permitted.

Main Results:

  • The mean fasting duration for clear liquids was 6.3 hours.
  • 24% of children exhibited a PAED score greater than 10.
  • PAED scores at 15 and 25 minutes post-anesthesia showed a significant correlation with preoperative fasting duration (p=0.02).

Conclusions:

  • Extended preoperative fasting may be a contributing risk factor for postoperative emergence delirium in pediatric patients undergoing ophthalmic surgery.
  • No correlation was found between fasting duration, blood glucose levels, and PAED scores.
Abstract

Related Concept Videos

Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
274
Pharmacokinetics in Pediatric Patients: Drug Distribution01:17

Pharmacokinetics in Pediatric Patients: Drug Distribution

Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight,...
330
Pharmacokinetics in Pediatric Patients: Drug Metabolism01:24

Pharmacokinetics in Pediatric Patients: Drug Metabolism

In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses...
245
Observational Studies01:11

Observational Studies

Observational studies are a type of analytical study where researchers observe events without any interventions. In other words, the researcher does not influence the response variable or the experiment's outcome.
There are three types of observational studies – Prospective, retrospective, and cross-sectional.
Prospective Study
Prospective studies, also known as longitudinal or cohort studies, are carried out by collecting future data from groups sharing similar characteristics. One...
11.1K
Correlations02:20

Correlations

Correlation means that there is a relationship between two or more variables (such as ice cream consumption and crime), but this relationship does not necessarily imply cause and effect. When two variables are correlated, it simply means that as one variable changes, so does the other. We can measure correlation by calculating a statistic known as a correlation coefficient. A correlation coefficient is a number from -1 to +1 that indicates the strength and direction of the relationship between...
36.5K
Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption01:23

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption

Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
307