Related Experiment Video
Updated: Feb 10, 2026

Quantification of Circulating Pig-Specific DNA in the Blood of a Xenotransplantation Model
Published on: September 22, 2020
First Use of HeartMate 3 in a Failing Fontan Circulation
Angela Lorts1, Chet Villa1, Kyle W Riggs1
1The Heart Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
Abstract:
The failing Fontan circulation can be challenging to support with ventricular assist devices, mostly because of the variety of causes of failure, some of which cannot be addressed by VAD therapy alone. A new ventricular assist device, the HeartMate 3 (Abbott, Chicago, IL), was recently approved for use in adults in the United States and is now widely available, with excellent survival results in two-ventricle patients. This case report describes the first successful implantation of the HeartMate 3 in a 22-year-old man with a failing Fontan circulation and the possible benefits this device may have in supporting this ever-growing population of young adults with single ventricles.
Related Concept Videos
Coronary Circulation
Coronary circulation begins at the base of the aorta, where two main arteries arise—the left and right coronary arteries. These arteries encircle the heart in the coronary sulcus and supply the...
Fetal Circulation
Two umbilical arteries transport blood from the fetus to the placenta. At the placenta, the blood absorbs oxygen and nutrients while simultaneously eliminating waste products. This oxygen-enriched and nutrient-rich blood then returns to the fetus through one...
Overview of Pulmonary Circulation
The process begins with the right ventricle of the heart pumping deoxygenated blood into the pulmonary trunk. This large vessel extends about 5 centimeters before splitting into the left and right pulmonary arteries. These arteries...
Overview of Systemic and Pulmonary Circulation
The oxygenated blood is sent...
ortho–para-Directing Activators: –CH3, –OH, –⁠NH2, –OCH3
Piaget's Stage 3 of Cognitive Development
Conservation and Constancy of Quantity
A significant cognitive milestone in the...

