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Serum TIMP1 and TIMP2 concentration in patients with different grades of meningioma

Farhad Mashayekhi1, Alia Saberi2, Sohail Mashayekhi2

  • 1Department of Biology, Faculty of Sciences, University of Guilan, Rasht, Iran.

Clinical Neurology and Neurosurgery
|May 13, 2018
PubMed
Abstract

Insights

Serum levels of tissue inhibitors of metalloproteinases (TIMP-1 and TIMP-2) were significantly lower in patients with higher-grade meningiomas. These findings suggest TIMP-1 and TIMP-2 may aid in classifying meningioma grades.

Area of Science:

  • Neuro-oncology
  • Biochemistry
  • Cancer Biology

Background:

  • Meningiomas are common primary brain tumors.
  • Matrix metalloproteinase-9 (MMP-9) promotes cancer invasion.
  • Tissue inhibitors of metalloproteinases (TIMPs) regulate MMPs.

Purpose of the Study:

  • To evaluate serum concentrations of TIMP-1 and TIMP-2 in meningioma patients.
  • To correlate TIMP levels with meningioma grade.

Main Methods:

  • Serum samples from 90 meningioma patients (grades I-III) and 51 healthy controls were analyzed.
  • Total protein concentration (TPC) was measured using Bio-Rad protein assay.
  • TIMP-1 and TIMP-2 levels were quantified using enzyme-linked immunosorbent assay (ELISA).

Main Results:

  • No significant difference in TPC was observed between patients and controls.
  • TIMP-1 and TIMP-2 were detected in all serum samples.
  • A significant decrease in TIMP-1 and TIMP-2 levels was observed with increasing meningioma grade (I to III) compared to controls.

Conclusions:

  • Lower serum expression of TIMP-1 and TIMP-2 correlates with advanced meningioma stages.
  • Serum TIMP-1 and TIMP-2 detection may assist in grading meningiomas.
  • Further research could explore TIMPs as biomarkers for meningioma progression.
Keywords:
ConcentrationMeningiomaSerumTIMP-1TIMP-2

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