Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Molecular Shapes01:18

Molecular Shapes

62.4K
Molecules have characteristic shapes that are crucial for their function. The arrangement of various electron groups around the central atom dictates their molecular geometry. Electron pairs in the valence shell of a central atom will adopt an arrangement that minimizes repulsions between the electron pairs by maximizing the distance between them. The valence electrons form either bonding pairs, located primarily between bonded atoms, or lone pairs.
Two regions of electron density in a diatomic...
62.4K
Statistical Significance01:50

Statistical Significance

22.2K
Once data is collected from both the experimental and the control groups, a statistical analysis is conducted to find out if there are meaningful differences between the two groups. A statistical analysis determines how likely any difference found is due to chance (and thus not meaningful). In psychology, group differences are considered meaningful, or significant, if the odds that these differences occurred by chance alone are 5 percent or less. Stated another way, if we repeated this...
22.2K
Fischer Projections02:18

Fischer Projections

16.7K
Learning to draw Fischer projections of molecules and understanding their relevance plays a crucial role in the visual depiction of organic molecules. A Fischer projection is a two-dimensional projection on a planar surface to simplify the three-dimensional wedge–dash representation of molecules. This is especially helpful in the case of molecules with multiple chiral centers that can be difficult to draw. Here, all the bonds of interest are represented as horizontal or vertical lines. While...
16.7K
Weighted Mean00:57

Weighted Mean

6.5K
While taking the arithmetic, geometric, or harmonic mean of a sample data set, equal importance is assigned to all the data points. However, all the values may not always be equally important in some data sets. An intrinsic bias might make it more important to give more weightage to specific values over others.
For example, consider the number of goals scored in the matches of a tournament. While computing the average number of goals scored in the tournament, it may be more important to...
6.5K
Newman Projections02:06

Newman Projections

21.3K
Different notations are used to represent the three-dimensional structure of molecules on two-dimensional surfaces. One of the most commonly used representations is the dash-wedge formula. The dashed wedges, solid wedges, and the plane lines indicate the groups situated behind the plane, coming out of the plane, and in the plane, respectively.
The organic molecules rotate across the single bonds leading to numerous temporary three-dimensional structures of varying energy known as...
21.3K
Probability in Statistics01:14

Probability in Statistics

23.5K
Probability is the likelihood of an event occurring. The term event is defined as a collection of results of a procedure. An event is a simple event when an outcome cannot be divided into simpler parts.
An example of a simple event is a coin toss. The result of a coin toss is either a head or a tail. Here, head and tail are two simple events. These two simple events make up the sample space. Further, the probability of an event occurring falls within the range of 0 to 1. The probability of an...
23.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Unlocking 3D baby face photogrammetry: Multi-view BabyMorph reconstruction from uncalibrated photographs.

Expert systems with applications·2026
Same author

Vision transformer embeddings and quantum pyramidal circuits for biomedical image analysis.

International journal of computer assisted radiology and surgery·2026
Same author

Disentangling metabolic impairment in the liver-heart axis: tissue-specific insulin sensitivity in type 2 diabetes.

Frontiers in endocrinology·2026
Same author

Vaccine hesitancy in the school community and among health personnel: a cross-sectional study.

BMC public health·2026
Same author

Exploring Serious Games in Supporting Postnatal Depression: Narrative Review.

Interactive journal of medical research·2026
Same author

A MultiRater MultiOrgan Abdominal CT Dataset for Calibration Analysis and Uncertainty Modeling in Segmentation.

Scientific data·2026
Same journal

Generative morphodynamic forecasting enables robust zero-shot volumetric medical segmentation.

Medical image analysis·2026
Same journal

ContiMorph: An unsupervised learning framework for cardiac motion tracking with time-continuous diffeomorphism.

Medical image analysis·2026
Same journal

MedP-CLIP: Medical CLIP with region-aware prompt integration.

Medical image analysis·2026
Same journal

Multi-organ guided diagnosis of mild cognitive impairment via hierarchical alignment and knowledge distillation.

Medical image analysis·2026
Same journal

SUDA: Simultaneous unsupervised knowledge distillation and adaptation of foundation models for efficient pathological image analysis.

Medical image analysis·2026
Same journal

Beyond the LUMIR challenge: The pathway to foundational registration models.

Medical image analysis·2026
See all related articles

Related Experiment Video

Updated: Feb 10, 2026

Long-term Culture of Human Breast Cancer Specimens and Their Analysis Using Optical Projection Tomography
10:10

Long-term Culture of Human Breast Cancer Specimens and Their Analysis Using Optical Projection Tomography

Published on: July 29, 2011

15.7K

Weighted regularized statistical shape space projection for breast 3D model reconstruction.

Guillermo Ruiz1, Eduard Ramon2, Jaime García2

  • 1Department of Information and Communication Technologies, Universitat Pompeu Fabra, Barcelona, Spain; Crisalix S.A., Lausanne, Switzerland.

Medical Image Analysis
|May 13, 2018
PubMed
Summary
This summary is machine-generated.

This paper introduces a new computational method to create accurate 3D digital models of human breasts. By using a technique called Weighted Regularized projection, the researchers allow surgeons to better incorporate specific patient landmarks into the reconstruction process. This approach works with both 2D photographs and 3D scans, helping improve the precision of surgical planning for plastic and aesthetic procedures.

Keywords:
3D morphable models3D reconstructionBreast imagingPlastic surgeryReconstructive surgeryShape constraintsStatistical shape modelssurgical planningstatistical shape modelsmedical imagingaesthetic surgery

Frequently Asked Questions

More Related Videos

Three-Dimensional Shape Modeling and Analysis of Brain Structures
05:33

Three-Dimensional Shape Modeling and Analysis of Brain Structures

Published on: November 14, 2019

7.6K
Endoscopic Bilateral Nipple-sparing Mastectomy via a Single Axillary Incision with Immediate Pre-pectoral Implant-based Breast Reconstruction
13:35

Endoscopic Bilateral Nipple-sparing Mastectomy via a Single Axillary Incision with Immediate Pre-pectoral Implant-based Breast Reconstruction

Published on: May 17, 2024

4.3K

Related Experiment Videos

Last Updated: Feb 10, 2026

Long-term Culture of Human Breast Cancer Specimens and Their Analysis Using Optical Projection Tomography
10:10

Long-term Culture of Human Breast Cancer Specimens and Their Analysis Using Optical Projection Tomography

Published on: July 29, 2011

15.7K
Three-Dimensional Shape Modeling and Analysis of Brain Structures
05:33

Three-Dimensional Shape Modeling and Analysis of Brain Structures

Published on: November 14, 2019

7.6K
Endoscopic Bilateral Nipple-sparing Mastectomy via a Single Axillary Incision with Immediate Pre-pectoral Implant-based Breast Reconstruction
13:35

Endoscopic Bilateral Nipple-sparing Mastectomy via a Single Axillary Incision with Immediate Pre-pectoral Implant-based Breast Reconstruction

Published on: May 17, 2024

4.3K

Area of Science:

  • Medical imaging informatics within breast 3D model reconstruction
  • Computational geometry and statistical shape analysis

Background:

Current surgical planning often lacks precise methods for translating patient anatomy into accurate digital representations. While three-dimensional imaging provides utility, existing techniques frequently struggle to incorporate specific anatomical constraints effectively. That uncertainty drove the need for more robust model-based reconstruction frameworks. Prior research has shown that statistical shape models offer a reliable foundation for capturing complex biological structures. However, these models often fail to prioritize known landmarks during the fitting process. This gap motivated the development of strategies that integrate prior information to improve geometric accuracy. No prior work had resolved how to balance general shape priors with specific, high-confidence anatomical data points. Researchers now seek to refine these reconstructions to better support aesthetic and plastic surgery workflows.

Purpose Of The Study:

The aim of this study is to present a framework for fitting statistical breast models to patient-specific data. Researchers sought to address the limitations of standard reconstruction methods that often ignore vital anatomical landmarks. This work addresses the need for improved accuracy in digital representations used for surgical planning. The authors were motivated by the potential for better communication between surgeons and patients during aesthetic consultations. They focused on developing a method that can utilize both two-dimensional photos and three-dimensional scans. By imposing shape constraints, the team intended to refine the fitting process of statistical models. This effort aims to provide a more reliable tool for simulating plastic surgery procedures. The study explores how weighting specific points can enhance the fidelity of the final digital output.

Main Methods:

The authors developed a framework utilizing Weighted Regularized projection to fit statistical shapes to patient data. This review approach focuses on integrating known landmarks into the reconstruction pipeline. The team implemented the algorithm to handle both two-dimensional images and three-dimensional point clouds. They applied the projection technique at multiple stages, beginning with the initialization of the statistical model. The researchers assigned specific weights to individual points to prioritize high-confidence anatomical regions. This strategy ensures that reliable shape information remains preserved throughout the fitting process. The design allows for the imposition of geometric constraints that guide the model toward the patient's unique anatomy. The study validates this approach by testing the framework across two distinct input settings to confirm its operational robustness.

Main Results:

Key findings from the literature indicate that the weighted projection method successfully improves the fitting accuracy of breast models. The researchers confirmed that their approach effectively incorporates prior information from both scans and photographs. The framework demonstrated high performance when initializing models from sparse point sets. By assigning higher relevance to specific points, the system maintained critical shape details that standard models often overlook. The results show that the weighted constraints lead to more precise representations of patient anatomy. The authors reported positive outcomes across all tested reconstruction frameworks. These findings suggest that the method is highly adaptable to different clinical data sources. The data confirm that the integration of known landmarks is a viable strategy for enhancing digital surgical planning tools.

Conclusions:

The authors propose that their weighted projection framework significantly enhances the accuracy of breast model fitting. Synthesis and implications suggest that incorporating specific landmarks allows for more precise anatomical representations. The researchers demonstrate that their approach successfully handles both sparse point clouds and two-dimensional photographic data. This flexibility indicates potential for broader application in various clinical imaging scenarios. The study confirms that prioritizing reliable regions preserves essential shape information during the reconstruction process. These findings imply that surgeons can achieve better patient-specific models by applying these constraints. The authors conclude that their method provides a robust tool for improving communication during surgical planning. Future applications may benefit from the integration of these weighted constraints into existing clinical software suites.

The researchers propose a Weighted Regularized projection mechanism. This approach assigns specific importance to individual points within the statistical model, allowing surgeons to enforce anatomical constraints during the fitting process, which improves the overall accuracy of the resulting breast reconstruction compared to standard unweighted methods.

The authors utilize 3D Morphable Models (3DMM) as the primary statistical foundation. This tool acts as a mathematical template that captures the natural variation of breast shapes, which the new projection method then refines by incorporating specific patient-derived landmarks or point cloud data.

A sparse set of 3D points is necessary for the initial stage of the process. This specific data type provides the foundational geometry required to anchor the statistical model before the system performs the final, more detailed fitting to the patient's anatomy.

The framework processes two distinct input types: 2D photographs and 3D scans. While scans offer direct spatial data, the 2D images require the system to infer depth, demonstrating the versatility of the weighted projection in handling different levels of information density.

The researchers measure reconstruction success by assessing the fitting precision of the model against known landmarks. This phenomenon evaluates how well the mathematical projection preserves the specific shape information of the patient compared to the original, unconstrained statistical model.

The authors claim that their method improves communication between surgeons and patients. By creating more accurate visual representations, the researchers propose that the planning process becomes more transparent, helping both parties align expectations regarding the final aesthetic outcomes of plastic surgery procedures.