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Denosumab-Associated Severe Hypocalcemia in a Patient With Chronic Kidney Disease

Sohail Abdul Salim1, Lakshmi Ramachandran Nair2, Litty Thomas1

  • 1Department of Internal Medicine, Division of Nephrology, University of Mississippi Medical Center, Jackson, Mississippi.

The American Journal of the Medical Sciences
|May 14, 2018
PubMed

Insights

Denosumab, a bone metastasis treatment, can cause hypocalcemia. This case study highlights severe, asymptomatic hypocalcemia in a patient with chronic kidney disease after denosumab treatment.

Area of Science:

  • Oncology
  • Nephrology
  • Pharmacology

Background:

  • Denosumab is a monoclonal antibody targeting RANKL, used to prevent skeletal events in bone metastases.
  • Hypocalcemia is a recognized side effect of denosumab, affecting 8-14% of patients.
  • Chronic kidney disease (CKD) can exacerbate calcium dysregulation.
Keywords:
Alkaline phosphataseEnd-stage renal diseaseHypercalcemia of malignancyParathyroid hormoneRANKL inhibitor

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