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The cingulum bundle: Anatomy, function, and dysfunction.

Emma J Bubb1, Claudia Metzler-Baddeley1, John P Aggleton1

  • 1School of Psychology, Cardiff University, 70 Park Place, Cardiff, CF10 3AT, Wales, UK.

Neuroscience and Biobehavioral Reviews
|May 14, 2018
PubMed
Summary
This summary is machine-generated.

The cingulum bundle, a key white matter tract, connects brain regions involved in cognition and emotion. Damage causes mild deficits, suggesting parallel pathways support its functions.

Keywords:
AgingAlzheimer’s diseaseAmygdalaCingulate gyrusDiffusion imagingEmotionHippocampusMemoryPrefrontal cortexPsychiatryRetrosplenial cortexWhite matter

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Area of Science:

  • Neuroscience
  • Neuroanatomy
  • White Matter Tracts

Background:

  • The cingulum bundle is a major white matter tract connecting frontal, parietal, and medial temporal regions.
  • It links subcortical nuclei to the cingulate gyrus, playing a role in various brain functions.
  • Its complex structure involves fibers continuously joining and leaving the bundle.

Purpose of the Study:

  • To review the complex structure and connections of the cingulum bundle.
  • To analyze the impact of cingulum bundle damage across species (rats, monkeys, humans).
  • To explore the cingulum bundle's role in cognitive and emotional functions using neuroimaging and clinical studies.

Main Methods:

  • Comparative anatomical descriptions of cingulum bundle connections.
  • Analysis of lesion studies in animal models and humans.
  • Review of non-invasive imaging and clinical data implicating the cingulum bundle.

Main Results:

  • Cingulum bundle lesions cause significant anatomical disconnections but only mild functional deficits.
  • Parallel pathways and distributed networks likely compensate for cingulum bundle damage.
  • The dorsal cingulum is implicated in executive control, emotion, and pain; the parahippocampal cingulum in episodic memory.

Conclusions:

  • The cingulum bundle's functions are distributed, with parallel pathways contributing to resilience against damage.
  • Abnormalities in the cingulum bundle are associated with various neurological and psychiatric conditions.
  • Further research is needed to precisely delineate pathways within the cingulum bundle to understand its diverse roles.