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Related Experiment Video

Updated: Feb 10, 2026

Using Chicken Embryo as a Powerful Tool in Assessment of Developmental Cardiotoxicities

Using Chicken Embryo as a Powerful Tool in Assessment of Developmental Cardiotoxicities

Published on: March 21, 2021

Best practices for developmental toxicity assessment for classification and labeling.

George Daston¹, Aldert Piersma², Leonello Attias³

¹Procter & Gamble, Cincinnati, OH, USA.

Reproductive Toxicology (Elmsford, N.Y.)

|May 14, 2018

Summary

Improving the assessment of developmental toxicity data is crucial for chemical hazard classification in Europe. Recommendations focus on enhancing data quality, understanding maternal toxicity, and ensuring human relevance for better public health protection.

Keywords:

Classification and labeling Developmental toxicity

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Area of Science:

Toxicology
Risk Assessment
Chemical Safety

Background:

European chemical regulation involves hazard-based classification and labeling.
Accurate assessment of developmental toxicity data is vital for public health.
Existing methods require refinement for robust interpretation.

Purpose of the Study:

To establish best practices for assessing developmental toxicity data.
To address challenges in chemical classification and labeling.
To enhance the scientific rigor of regulatory assessments.

Main Methods:

Co-organized workshop by the European Teratology Society and Health and Environmental Sciences Institute.
Discussion on data quality, consistency, and interpretation of developmental effects.
Consideration of maternal toxicity, human relevance of animal data, and chemical class limits.

Main Results:

Recommendations for larger historical control databases.
Emphasis on pharmacokinetic studies in pregnant animals for dose setting.
Call for mechanistic data to clarify maternal toxicity's role in developmental effects.

Conclusions:

Proposed improvements for data interpretation in chemical classification and labeling.
Need for more rigorous specifications for chemical classes.
Foundation laid for future consensus workshops to enhance scientific robustness.