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Peptidome Analysis Reveals Novel Serum Biomarkers for Children with Autism Spectrum Disorder in China

Juan Yang1,2, Yanni Chen3, Xiaofan Xiong1

  • 1Department of Cell Biology and Genetics, School of Basic Medical Sciences/Key Laboratory of Environment and Genes Related to Diseases, Xi'an Jiaotong University Health Science Center, Xi'an, 710061, Shaanxi, China.

Proteomics. Clinical Applications
|May 14, 2018
PubMed

Insights

Researchers identified eight potential autism spectrum disorder (ASD) serum biomarkers in children. These protein biomarkers could aid in early ASD diagnosis and understanding the disorder's biological basis.

Area of Science:

  • * Neuroscience
  • * Biochemistry
  • * Genetics

Background:

  • * Autism spectrum disorder (ASD) is a lifelong neurodevelopmental condition.
  • * Early diagnosis and intervention are crucial for improving language and social skills in children with ASD.
  • * The absence of specific biomarkers currently hinders early ASD diagnosis.

Purpose of the Study:

  • * To identify novel serum biomarkers for the early diagnosis of autism spectrum disorder (ASD).
  • * To investigate the proteomic profile of serum in children with ASD compared to healthy controls.

Main Methods:

  • * Serum samples from Han Chinese children diagnosed with ASD (n=68) and age-matched healthy controls (n=80) were analyzed.
  • * Magnetic bead-based separation coupled with mass spectrometry was employed for proteomic analysis.
  • * Potential biomarker candidates were validated using enzyme-linked immunosorbent assay (ELISA).

Main Results:

  • * Eight distinct serum biomarker peaks were identified with higher expression in the ASD group.
  • * These peaks correspond to specific proteins including SERPINA5, PF4, FABP1, APOC1, AFP, CPB2, TAAR6, and FGA.
  • * Enzyme-linked immunosorbent assay (ELISA) confirmed the expression levels of these identified proteins.

Conclusions:

  • * The study reveals unique aspects of ASD etiology from a serum proteomic viewpoint.
  • * The identified proteins show potential as diagnostic biomarkers for autism spectrum disorder.
  • * Further research is warranted to validate these findings and explore their clinical utility.
Abstract

Keywords:
ASDearly diagnosismass spectrumserum biomarker

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