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Preparation of Nanoparticles for ToF-SIMS and XPS Analysis
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Nanoparticle Wettability Influences Nanoparticle-Phospholipid Interactions.

Nagarjun V Konduru, Flavia Damiani, Svetla Stoilova-McPhie1

  • 1Center for Nanoscale Systems, Faculty of Art and Sciences , Harvard University , 11 Oxford Street , Cambridge , Massachusetts 02138 , United States.

Langmuir : the ACS Journal of Surfaces and Colloids
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Summary

Nanoparticle (NP) surface hydrophobicity, not charge, dictates how much and what type of phospholipids adsorb to NPs. This influences how NPs interact with lipid bilayers, impacting their biological behavior.

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Area of Science:

  • Materials Science
  • Biomaterials Science
  • Nanotechnology

Background:

  • Understanding nanoparticle-biomolecule interactions is crucial for predicting nanoparticle behavior in biological systems.
  • Surface properties of nanoparticles, such as charge and hydrophobicity, significantly influence their interactions with biological molecules.

Purpose of the Study:

  • To investigate the impact of nanoparticle surface charge and hydrophobicity on phospholipid adsorption.
  • To characterize the interactions between various nanoparticles and lipids using advanced microscopy techniques.

Main Methods:

  • Exposure of nanoparticles (CeO2, ZnO, BaSO4, silica-coated CeO2) to rat bronchoalveolar lavage fluid (BALf) and a phospholipid mixture (DPPC/DPPA).
  • Analysis of adsorbed phospholipids using cryogenic transmission electron microscopy (cryo-TEM) and atomic force microscopy (AFM).

Main Results:

  • Higher lipid adsorption was observed on more hydrophobic CeO2 nanoparticles compared to others.
  • Adsorbed lipid composition differed from the bulk fluid, with sphingomyelin notably absent.
  • Hydrophobic NPs (CeO2) associated with multilamellar vesicles, while less hydrophobic NPs (BaSO4) interacted with unilamellar vesicles.

Conclusions:

  • Nanoparticle surface hydrophobicity is the primary determinant of adsorbed lipid quantity and type.
  • Surface hydrophobicity governs the structural organization of lipid interactions with nanoparticles.
  • These findings are critical for understanding nanoparticle fate and effects in biological environments.