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Detection of Targetable Alterations in Non-small Cell Lung Cancer using Next-generation Sequencing
05:17

Detection of Targetable Alterations in Non-small Cell Lung Cancer using Next-generation Sequencing

Published on: October 10, 2025

424

Detecting resistance in EGFR-mutated non-small-cell lung cancer after clonal selection through targeted therapy

Justine L Kuiper1, Idris Bahce1, Charlotte Voorhoeve2

  • 1Department of Pulmonary Diseases, VU University Medical Center, Amsterdam, The Netherlands.

Personalized Medicine
|May 15, 2018
PubMed

Insights

Tumor heterogeneity contributes to treatment resistance. A novel nuclear imaging technique shows promise for detecting this heterogeneity in clinical practice.

Area of Science:

  • Oncology
  • Medical Imaging
  • Molecular Biology

Background:

  • Tumor heterogeneity is a significant factor in developing resistance to targeted therapies.
  • Current clinical practice lacks effective methods to integrate tumor heterogeneity insights.
  • Understanding and addressing tumor heterogeneity is crucial for improving cancer treatment outcomes.

Purpose of the Study:

  • To introduce an innovative nuclear imaging method for detecting tumor heterogeneity.
  • To explore the potential of this new imaging approach in clinical oncology.
  • To provide a future direction for managing treatment-resistant cancers.

Main Methods:

  • Development of a novel nuclear imaging technique.
  • Application of the imaging method to assess tumor characteristics.
  • Evaluation of the method's capability in identifying heterogeneity patterns.

Main Results:

  • The described nuclear imaging method demonstrated potential in detecting tumor heterogeneity.
  • The technique offers a new avenue for visualizing complex tumor characteristics.
  • Further validation is needed to establish its clinical utility.

Conclusions:

  • The innovative nuclear imaging method may aid in detecting tumor heterogeneity.
  • This approach could potentially guide treatment strategies for resistant tumors.
  • Future research will focus on clinical translation and validation of the technique.
Keywords:
biopsyheterogeneityimagingmutationnon-small-cell lung cancer

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