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Updated: Feb 10, 2026

Ferric Chloride-induced Murine Thrombosis Models
Published on: September 5, 2016
[Huge Left Thrombosis after Mitral Valvuloplasty and Maze Procedure;Report of a Case]
Hitomi Naruse1, Noriyasu Kawada, Koichi Muramatsu
1Department of Cardiac Surgery, The Kashiwa Hospital of the Jikei University School of Medicine, Kashiwa, Japan.
Insights
Anticoagulation therapy may be necessary after mitral valvuloplasty, even in sinus rhythm. A patient with a large left atrium developed left atrial thrombosis, highlighting the need for careful monitoring and potential anticoagulation in select cases.
Area of Science:
- Cardiology
- Cardiac Surgery
- Thrombosis Research
Background:
- Mitral valvuloplasty is a common procedure for mitral valve regurgitation.
- Anticoagulation is typically not required for patients in sinus rhythm post-procedure.
- Atrial fibrillation management often involves procedures like the maze procedure.
Observation:
- A 66-year-old woman developed left atrial thrombosis 4 years after mitral valvuloplasty and maze procedure.
- The patient maintained sinus rhythm, challenging the standard post-procedure care guidelines.
- Echocardiography revealed a narrow mitral valve area, absent A wave, and a significantly enlarged left atrium.
Findings:
- Left atrial thrombosis was present despite the absence of atrial fibrillation.
- The thrombus was large and attached to the left atrial wall, independent of the maze procedure ablation lines.
- These findings suggest that factors beyond rhythm status, such as left atrial size and valve condition, are critical.
Implications:
- Patients with large left atria or rheumatic mitral valves post-valvuloplasty require vigilant monitoring, including echocardiography.
- Consideration of anticoagulation therapy may be warranted in these high-risk patients, irrespective of sinus rhythm maintenance.
- This case underscores the complexity of thromboembolic risk assessment after mitral valve interventions.
Abstract:
Generally, anticoagulation therapy is not essential for patients who maintain sinus rhythm after mitral valvuloplasty. A 66-year-old woman who had undergone mitral valvuloplasty and maze procedure for treatment of mitral valve regurgitation and atrial fibrillation 4 years ago was diagnosed as having left atrial thrombosis despite maintenance of sinus rhythm on electrocardiography. Echocardiography showed narrow mitral valvular area(1.5 cm2), loss of A wave and a huge left atrium. Repeat surgery was performed to replace the mitral valve and to remove the thrombus. The thrombus attached to the posterior wall of the left atrium with a wide basis, and was unrelated to the ablation line of maze procedure. Careful follow-up and anticoagulation therapy should be considered for patients who have a large left atrium and/or rheumatic mitral valve after valvuloplasty even though sinus rhythm is maintained.
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