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Updated: Feb 10, 2026

Modeling Charcot-Marie-Tooth Disease In Vitro by Transfecting Mouse Primary Motoneurons
Published on: January 7, 2019
Charcot spinal arthropathy
Dennis Lee1, Nader S Dahdaleh2
1Department of Neurological Surgery, Chicago Medical School, Rosalind Franklin University of Medicine and Science, Illinois, Chicago, USA.
Abstract:
Charcot spinal arthropathy (CSA) is a rare progressive disorder of vertebral joint degeneration that occurs in the setting of any condition characterized by decreased afferent innervation with loss of deep pain and proprioceptive sensation in the vertebral column. While surgical circumferential arthrodesis remains the most effective treatment modality, it is associated with multiple complications, including hardware construct failure. This manuscript represents an up-to-date narrative review of the treatment of CSA, its associated complications, and complication prevention.
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