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Androgen-Induced Immunosuppression.

Melanie R Gubbels Bupp1, Trine N Jorgensen2

  • 1Biology Department, Randolph Macon College, Ashland, VA, United States.

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|May 15, 2018
PubMed
Summary
This summary is machine-generated.

Sex hormones, particularly androgens, significantly impact immune cell function and autoimmune disease prevalence. Understanding androgen receptor roles is key to explaining sex-based differences in immune-mediated conditions.

Keywords:
androgenautoimmunitycancermultiple sclerosisrheumatoid arthritissex hormonessystemic lupus erythematosustestosterone

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Area of Science:

  • Immunology
  • Endocrinology
  • Sex Differences in Disease

Background:

  • Sex hormones influence immune cell activity and organ susceptibility to immune-mediated damage.
  • Systemic autoimmune disorders (lupus, rheumatoid arthritis, multiple sclerosis) are more common in females, while cancer is more prevalent in males.
  • Sex hormones are implicated in these sex-based disparities in disease prevalence.

Purpose of the Study:

  • To review the mechanisms by which androgens and androgen receptor expression affect immune cells.
  • To explore how these effects may alter immune responses.
  • To understand the role of androgens in autoimmune disease incidence and progression.

Main Methods:

  • Literature review focusing on androgen and androgen receptor effects on immune cells.
  • Analysis of existing research on sex hormone influence on immune-mediated diseases.
  • Synthesis of findings related to immune response modulation and disease progression.

Main Results:

  • Androgens and functional androgen receptor expression can modulate immune cell activity.
  • These modulations may dampen or alter immune responses.
  • Evidence suggests a role for androgens in influencing the incidence and progression of autoimmune diseases.

Conclusions:

  • Androgens play a significant role in regulating immune responses.
  • Androgen receptor signaling is a critical factor in sex-based differences in immune-mediated diseases.
  • Further research into androgen pathways may offer insights into treating autoimmune disorders.