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Adjunctive Platelet-Rich Plasma (PRP) in Infrabony Regenerative Treatment: A Systematic Review and RCT's
Mubashir Saleem1, Flavio Pisani1, Faisal Maqbool Zahid2
1Faculty of Dentistry, School of Health, MClinDent in Periodontology, BPP University Birmingham, Birmingham, UK.
Stem Cells International
|May 15, 2018
Summary
Platelet-rich plasma (PRP) shows potential benefits in regenerating infrabony periodontal defects, particularly when used with bone grafts. Further research is needed to confirm its clinical efficacy and optimal application in periodontal regeneration.
Area of Science:
- Periodontology
- Regenerative Medicine
- Biomaterials Science
Background:
- Infrabony periodontal defects present a significant challenge in restorative dentistry.
- Platelet-rich plasma (PRP), a concentration of growth factors derived from autologous blood, is explored for its regenerative potential.
Purpose of the Study:
- To evaluate the clinical performance of platelet-rich plasma (PRP) as an adjunct in regenerating infrabony periodontal defects.
- To compare outcomes with different biomaterials and surgical flap approaches, with and without PRP.
Main Methods:
- A systematic meta-analysis was conducted, including 15 studies selected from 73 articles.
- Electronic and hand searches were performed up to December 2016, with quality assessment using the Jadad scale.
Main Results:
- Adjunctive PRP demonstrated superior performance in clinical attachment level (CAL) gain and probing pocket depth (PPD) reduction when used with bone grafts.
- No significant difference in outcomes was observed based on the surgical flap approach used.
Conclusions:
- While PRP is a cost-effective, autologous growth factor source, conclusive data on its benefits in infrabony defects are still emerging.
- PRP may offer clinical advantages in regenerative periodontal surgery, potentially enhancing outcomes and reducing the need for additional biomaterials.
