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Related Concept Videos

Hypertension I: Introduction01:28

Hypertension I: Introduction

953
Hypertension is a widespread, long-term medical condition where blood pressure in the arteries remains elevated. It is characterized by systolic blood pressure readings of 130 mm Hg or above or diastolic blood pressure (DBP) readings of 80 mm Hg or higher. Unmanaged hypertension poses significant health risks, making the distinction between primary (or essential) hypertension and secondary hypertension crucial, as their management and implications vary.Primary HypertensionPrimary hypertension,...
953
Hypertension II: Pathophysiology01:29

Hypertension II: Pathophysiology

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Hypertension is a chronic condition in which the blood's force against artery walls is excessively high, posing risks such as heart disease. The condition's underlying mechanisms involve complex interactions among the cardiovascular, kidney, and autonomic nervous systems.Renin-Angiotensin-Aldosterone System (RAAS): This system significantly influences blood pressure regulation. When blood pressure decreases, the kidneys secrete renin. This enzyme transforms angiotensinogen, a plasma protein,...
1.0K
Hypertension V: Nursing Management01:23

Hypertension V: Nursing Management

482
The nursing management of hypertension involves accurately assessing symptoms, making a comprehensive nursing diagnosis, collaborating with patients to set goals, and implementing targeted interventions to mitigate the condition's impact and improve patient well-being.Comprehensive AssessmentThe initial step in nursing care for hypertension involves a thorough patient assessment. It includes evaluating symptoms such as headaches, dizziness, blurred vision, and previous hypertension episodes.
482
Hypertension and Regulation of Blood Pressure01:18

Hypertension and Regulation of Blood Pressure

4.5K
Hypertension, the most common cardiovascular disease, is diagnosed through repeated measurements of elevated blood pressure. Its risks, including damage to the kidney, heart, and brain, are directly proportional to blood pressure levels. Starting from 115/75 mm Hg, the risk of cardiovascular disease doubles with each increment of 20/10 mm Hg. The diagnosis relies on blood pressure measurements, not on patient symptoms, as hypertension is often asymptomatic until end-organ damage is imminent or...
4.5K
Pulmonary Hypertension: Classification and Pathogenesis01:30

Pulmonary Hypertension: Classification and Pathogenesis

664
Pulmonary hypertension (PH) is a severe health condition in which the mean pulmonary arterial pressure increases to 25 mmHg or more, even when the body is at rest. This high pressure in the blood vessels that transport blood from the heart to the lungs can cause various symptoms, including shortness of breath, can lead to right heart failure, and significantly affect the overall quality of life.
There are various classifications for PH, each relating to different underlying causes and also...
664
Hypertension III: Clinical Manifestations and Diagnostic Studies01:30

Hypertension III: Clinical Manifestations and Diagnostic Studies

608
Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
608

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Hypertension in malignancy-an underappreciated problem.

Jolanta Małyszko1,2, Maciej Małyszko1, Leszek Kozlowski3

  • 12nd Department of Nephrology and Hypertension with Dialysis Unit, Medical University in Bialystok, Bialystok, Poland.

Oncotarget
|May 15, 2018
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Summary

Hypertension is a common comorbidity and side effect of cancer treatments. Managing blood pressure in cancer patients requires individualized antihypertensive therapy based on specific conditions and treatment regimens.

Keywords:
hypertensionmalignancy

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Area of Science:

  • Oncology
  • Cardiology
  • Pharmacology

Background:

  • Hypertension is a frequent comorbidity in cancer patients, especially the elderly.
  • Antineoplastic treatments, including chemotherapy and targeted agents, can cause or worsen hypertension.
  • Anti-angiogenic therapies, particularly anti-VEGF treatments, commonly lead to hypertension, though its exact mechanisms are still under investigation.

Purpose of the Study:

  • To review the causes and management of hypertension in cancer patients undergoing antineoplastic treatment.
  • To highlight the role of various cancer therapies in inducing or exacerbating hypertension.
  • To emphasize the importance of individualized antihypertensive strategies in this population.

Main Methods:

  • Review of existing literature on hypertension in cancer patients.
  • Analysis of the impact of chemotherapy, targeted agents, and adjuvant drugs on blood pressure.
  • Discussion of antihypertensive treatment considerations based on patient-specific factors.

Main Results:

  • Several chemotherapeutics and targeted drugs are implicated in hypertension development or worsening.
  • Anti-VEGF therapy is a frequent cause of hypertension, linked to multiple, not fully understood pathways.
  • Adjuvant medications like steroids and ESAs can also elevate blood pressure.
  • Hypertension development has been inconsistently associated with improved antitumor efficacy in anti-angiogenic drug trials.

Conclusions:

  • Antihypertensive therapy is essential for managing cancer patients with hypertension during antineoplastic treatment.
  • Treatment decisions must consider organ dysfunction, comorbidities, adverse effects, hypertension severity, and urgency.
  • While specific guidelines are lacking, individualized therapy following general hypertension guidelines is crucial for optimal outcomes.