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Updated: Feb 10, 2026

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Published on: October 17, 2025
Cytomegalovirus Colitis Masquerading as Apple-Core Lesion after Systemic Chemotherapy in a Patient with Relapsed
Jong An1, Jason Brownell2, Darrell Barker3
1Department of Hematology and Oncology Service, San Antonio Military Medical Center, Fort Sam Houston, San Antonio, TX 78234, USA.
Abstract:
We report the case of a 71-year-old male with relapsed acute myeloid leukemia who developed cytomegalovirus (CMV) colitis presenting as an apple-core lesion during induction chemotherapy. CMV infection occurs rarely during induction chemotherapy for acute myeloid leukemia. CMV infection is usually observed in patients with acquired immune deficiency syndrome (AIDS) and in those on immunosuppressive agents following bone marrow transplant. Although rare, CMV colitis should be considered in patients who are critically ill after systemic chemotherapy as it can cause significant morbidity and mortality.
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