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Published on: July 3, 2013
Very low-protein diet to postpone renal failure: Pathophysiology and clinical applications in chronic kidney disease
Vincenzo Bellizzi1,2, Patrizia Calella3, Juan Jesus Carrero2,4
1Nephrology Unit, University Hospital "San Giovanni di Dio e Ruggi d'Aragona", Salerno 84131, Italy.
Abstract:
The uremic syndrome is a metabolic disorder characterized by the impairment of renal handling of several solutes, the resulting accumulation of toxic products and the activation of some adaptive but detrimental mechanisms which all together contribute to the progression of renal damage. In moderate to advanced renal failure, the dietary manipulation of nutrients improves metabolic abnormalities and may contribute to delay the time of dialysis initiation. This commentary focuses on the physiopathological rationale and the clinical application of the very low-protein diet supplemented with ketoanalogs for the management of chronic kidney disease.
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