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Updated: Feb 10, 2026

Models and Methods to Evaluate Transport of Drug Delivery Systems Across Cellular Barriers
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Models and Methods to Evaluate Transport of Drug Delivery Systems Across Cellular Barriers

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Biopolymers for Antitumor Implantable Drug Delivery Systems: Recent Advances and Future Outlook

Sepehr Talebian1,2, Javad Foroughi1,2, Samantha J Wade2,3

  • 1Intelligent Polymer Research Institute, ARC Centre of Excellence for Electromaterials Science, AIIM Facility, University of Wollongong, NSW 2522, Australia.

Advanced Materials (Deerfield Beach, Fla.)
|May 15, 2018
PubMed

Insights

Biopolymer-based implantable drug delivery systems (DDSs) offer a promising approach to combat cancer by enabling localized drug delivery, reducing systemic toxicity, and preventing tumor recurrence.

Area of Science:

  • Biomaterials Science
  • Oncology
  • Drug Delivery Systems

Background:

  • Cancer remains a leading cause of death globally, despite treatment advances.
  • Current cancer therapies often cause severe systemic toxicity and struggle to prevent disease recurrence.
  • Biomaterial-based implantable drug delivery systems (DDSs) offer localized administration directly to the tumor site.

Purpose of the Study:

  • To review recent advances in biopolymer-based DDSs for cancer treatment.
  • To discuss novel biopolymers and microdevices for implantable antitumor DDSs.
  • To explore new therapeutic modalities utilizing implantable biopolymeric DDSs.

Main Methods:

  • Review of recent scientific literature on biopolymer-based DDSs.
  • Discussion of emerging biopolymers and polymeric microdevices.
  • Analysis of implantable DDSs for tumor growth suppression and recurrence prevention.

Main Results:

  • Biopolymers enable precise spatiotemporal control over drug release in implantable DDSs.
  • Biopolymer-based DDSs show promise in suppressing tumor growth.
  • These systems are effective in preventing tumor recurrence.

Conclusions:

  • Biopolymer-based implantable DDSs represent a significant advancement in localized cancer therapy.
  • Novel biopolymers and microdevices are expanding the potential of these systems.
  • This therapeutic modality offers a new strategy to improve cancer treatment outcomes.
Keywords:
3D printingbiopolymerscancerdrug deliveryelectrospinningimplantsinjectable gels

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