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Safety of preoperative ibuprofen in pediatric tonsillectomy

Alexander Michael1, Farrel J Buchinsky1, Glenn Isaacson1,2

  • 1Department of Otolaryngology-Head and Neck Surgery, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, U.S.A.

The Laryngoscope
|May 15, 2018
PubMed

Insights

Preoperative ibuprofen administration in children undergoing tonsillectomy did not increase bleeding risks. This safety finding supports further research into its effectiveness for pain management in pediatric adenotonsillectomy.

Area of Science:

  • Pediatric Otolaryngology
  • Pain Management
  • Pharmacology

Background:

  • Oral ibuprofen is commonly used post-adenotonsillectomy.
  • Limited data exists on its preoperative use as an analgesic.
  • Safety of preoperative ibuprofen in pediatric tonsillectomy requires investigation.

Purpose of the Study:

  • To evaluate the safety of preoperative oral ibuprofen in pediatric adenotonsillectomy.
  • To compare bleeding rates between children receiving and not receiving preoperative ibuprofen.

Main Methods:

  • Retrospective case-control study of 217 children undergoing tonsillectomy or adenotonsillectomy.
  • Control group (n=112) received no preoperative ibuprofen.
  • Study group (n=105) received 7 mg/kg oral ibuprofen preoperatively.

Main Results:

  • No significant intraoperative or early postoperative bleeding occurred in either group.
  • Bleeding rates were comparable between the ibuprofen and control cohorts (95% CI 0-0.029 and 0-0.027, respectively).
  • Delayed bleeding rates were similar in both groups.

Conclusions:

  • Preoperative ibuprofen in pediatric tonsillectomy patients is not associated with increased bleeding.
  • Favorable safety profile suggests further study on its analgesic efficacy.
  • Future research should focus on pain reduction and opioid requirements.
Abstract

Keywords:
Analgesiaibuprofenpainpost-tonsillectomy bleeding

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