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Detection of Protein S-Acylation using Acyl-Resin Assisted Capture
Published on: April 10, 2020
Acylation of Homoatomic Ge9 Cages and Subsequent Decarbonylation
Sabine Frischhut1, Wilhelm Klein1, Markus Drees2
1Lehrstuhl für Anorganische Chemie mit Schwerpunkt Neue Materialien, Fakultät für Chemie, Technische Universität München, Lichtenbergstraße 4, 85747, Garching, Germany.
Abstract:
The direct acylation of Ge9 Zintl clusters by the reaction of K[Ge9 {Si(SiMe3 )3 }3 ] with acyl chlorides in hexane or toluene solutions is presented, leading to the neutral, carbonyl-derivatized products [{Si(SiMe3 )3 }3 Ge9 (CO)R'] (R'=Me, iPr, tBu, Ph, Bz, cyclopropylmethyl, phenethyl, 4-vinylphenyl). This reaction is applicable to a wide range of acyl chlorides and allows for diverse functionalization of Ge9 Zintl clusters. [{Si(SiMe3 )3 }3 Ge9 (CO)tBu] readily releases CO at ambient conditions under formation of [{Si(SiMe3 )3 }3 Ge9 tBu]. This temperature-dependent decarbonylation most likely proceeds via a radical Norrish-type I α-bond cleavage. Except for R'=tBu and Bz all obtained acyl-derivatized Ge9 cluster compounds do not release CO even at elevated temperatures. All compounds were characterized by NMR spectroscopy. [{Si(SiMe3 )3 }3 Ge9 (CO)R'] (R'=tBu, Ph, Me, iPr) as well as [{Si(SiMe3 )3 }3 Ge9 tBu] were further structurally characterized by single crystal X-ray diffraction.
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