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Related Experiment Video

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Immunofluorescence to Monitor the Cellular Uptake of Human Lactoferrin and its Associated Antiviral Activity Against the Hepatitis C Virus
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Lactoferrin: Major Physiological Functions and Applications.

Liyuan Hao1, Qiang Shan1, Jingya Wei1

  • 1State Key Laboratory of Animal Nutrition, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing, China.

Current Protein & Peptide Science
|May 15, 2018
PubMed
Summary
This summary is machine-generated.

Lactoferrin (Lf), an iron-binding glycoprotein in milk, regulates iron absorption and immunity, offering antimicrobial, antiviral, and anti-inflammatory benefits. Its use in infant formula and as adjuvant therapy highlights its therapeutic potential.

Keywords:
Lactoferrin (Lf)anti-cancer effectanti-microbial effectanti-viral effectantioxidant effectapplicationimmunomodulatory functioniron-binding activity.

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Area of Science:

  • Biochemistry
  • Immunology
  • Nutritional Science

Background:

  • Lactoferrin (Lf) is an iron-binding glycoprotein found in milk and external secretions.
  • It plays crucial roles in iron absorption, immune modulation, and possesses antimicrobial, antiviral, antioxidant, anti-cancer, and anti-inflammatory properties.

Purpose of the Study:

  • To review the content, distribution, physiological functions, and current applications of lactoferrin.
  • To explore future prospects for additional applications of lactoferrin.

Main Methods:

  • Literature review of existing studies on lactoferrin.
  • Analysis of lactoferrin's biological roles and therapeutic uses.

Main Results:

  • Lactoferrin regulates intestinal iron absorption and chelates iron.
  • It modulates immune responses and exhibits broad-spectrum bioactivities.
  • Lactoferrin is utilized in nutraceutical-supplemented infant formula and as adjuvant therapy for intestinal diseases.

Conclusions:

  • Lactoferrin is a versatile biomolecule with significant physiological functions.
  • Its established applications and diverse bioactivities suggest potential for expanded therapeutic and nutritional uses.