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Updated: Feb 10, 2026

Facile Preparation of 2Z,4E-Dienamides by the Olefination of Electron-deficient Alkenes with Allyl Acetate
Published on: June 21, 2017
Ruthenium-catalyzed C-H allylation of arenes with allylic amines
1CAS Key Laboratory of Soft Matter Chemistry and Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, People's Republic of China. zxwang@ustc.edu.cn.
Abstract:
The Ru-catalyzed pyridyl-directed C-H allylation of arenes with allylic amines has been developed. This reaction was carried out in the presence of 5 mol% of [Ru(p-cymene)Cl2]2 and 0.5 equiv. of AgOAc in CF3CH2OH at 75 °C, affording the allylated products of arenes in moderate to excellent yields. The method exhibits a wide scope of allylic amines and arenes and shows a good compatibility of functional groups. The pyrazolyl- and pyrimidyl-directed C-H allylation of arenes was also performed under the same conditions.
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