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Related Experiment Video

Updated: Feb 10, 2026

Technique of Conjunctival Biopsy and Direct Immunofluorescence for Diagnosing Mucous Membrane Pemphigoid

Technique of Conjunctival Biopsy and Direct Immunofluorescence for Diagnosing Mucous Membrane Pemphigoid

Published on: June 17, 2025

Localized genital bullous pemphigoid.

S J Mounsey¹, K Heelan², S Hughes¹

¹Department of Dermatology, University College Hospitals, London, UK.

Clinical and Experimental Dermatology

|May 15, 2018

Summary

Genital bullous pemphigoid (GBP), a rare skin condition, typically affects women and children. This report details a rare case of GBP in an adult male, successfully treated with medication.

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Area of Science:

Dermatology
Immunodermatology
Autoimmune Blistering Diseases

Background:

Bullous pemphigoid (BP) is an autoimmune blistering disease targeting hemidesmosomes, crucial for epidermal adhesion.
Genital bullous pemphigoid (GBP) is a rare, localized variant of BP, predominantly reported in women and children.
The pathogenesis involves autoantibodies leading to subepidermal blistering and skin erosion.

Observation:

An adult male presented with a scrotal rash and blisters progressing to erosions.
This presentation is highly unusual, with only two prior documented cases in adult males.
Clinical and histological findings, along with immunofluorescence, confirmed the diagnosis of bullous pemphigoid.

Findings:

The patient's diagnosis of genital bullous pemphigoid was confirmed through standard diagnostic methods.
Treatment with mycophenolate mofetil and doxycycline resulted in a positive clinical response.
This case expands the limited literature on male genital bullous pemphigoid.

Implications:

Highlights the importance of considering GBP in adult males presenting with genital blistering lesions.
Demonstrates the efficacy of immunosuppressive therapy (mycophenolate mofetil) and antibiotics (doxycycline) in managing this rare condition.
Contributes to understanding the clinical spectrum and management of localized bullous pemphigoid variants.