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[Use of posaconazole in children: Experience in a tertiary pediatric hospital]

María T Rosanova1, Carla Voto2, María S Mussini2

  • 1Servicio de Control Epidemiológico e Infectología, Hospital "Prof. Dr. Juan P. Garrahan", Ciudad Autónoma de Buenos Aires, Argentina. margris2@yahoo.com.ar.

Archivos Argentinos De Pediatria
|May 15, 2018
PubMed

Insights

This study evaluated posaconazole use in pediatric invasive fungal infections. Posaconazole demonstrated clinical utility, with most patients tolerating the antifungal medication well.

Area of Science:

  • Pediatric Mycology
  • Infectious Diseases
  • Clinical Pharmacology

Background:

  • Limited data exists on pediatric use of posaconazole.
  • Invasive fungal infections (IFIs) pose significant risks in immunocompromised children.
  • Posaconazole is a broad-spectrum triazole antifungal agent.

Purpose of the Study:

  • To assess the clinical and microbiological characteristics of pediatric patients treated with posaconazole.
  • To evaluate the treatment outcomes and adverse effects of posaconazole in children with IFIs.

Main Methods:

  • Retrospective, descriptive study design.
  • Inclusion of 16 pediatric patients with proven IFIs treated between 2010 and 2017.
  • Analysis of patient demographics, underlying conditions, fungal pathogens, posaconazole dosage, treatment duration, and adverse events.

Main Results:

  • The median age of patients was 161 months; all had underlying diseases and IFIs.
  • Mucor spp. and Aspergillus spp. were the most common fungal isolates.
  • The mean posaconazole dose was 600 mg/day, with a median treatment duration of 223 days. Ten patients experienced adverse effects, with only one discontinuation due to electrolyte imbalance.

Conclusions:

  • Posaconazole can be a viable treatment option for invasive fungal infections in children.
  • The drug was generally well-tolerated in this pediatric cohort, with a low rate of treatment discontinuation due to adverse events.

Keywords:
childinvasive fungal infectionsposaconazoletreatment

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