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[Tuberculosis by multiresistant Mycobacterium africanum. Pediatric clinical case]

Júlia Morata Alba1, Paloma Beltrán Catalá2, Nelson Orta Sibú3

  • 1Servicio de Pediatría, Hospital Lluís Alcanyís, Xàtiva, Valencia, España. uliamorataalba@gmail.com.

Archivos Argentinos De Pediatria
|May 15, 2018
PubMed

Insights

Tuberculosis remains a global health emergency, particularly impacting developing nations. This case highlights a rare, multidrug-resistant Mycobacterium africanum infection in a child, successfully treated with combination therapy.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Public Health

Background:

  • Tuberculosis (TB) is a major global health emergency, causing millions of deaths annually, primarily in developing countries.
  • In Spain, pediatric TB incidence rates are notable, especially in children under 4 years.
  • Drug resistance, particularly to isoniazid, is a concern, especially within immigrant populations.

Observation:

  • A case of tuberculosis caused by Mycobacterium africanum was observed.
  • This specific strain exhibited multidrug resistance to standard treatments.
  • The patient was a child within the Spanish pediatric population.

Findings:

  • The pediatric case involved Mycobacterium africanum, a less common cause of TB.
  • The identified strain was multiresistant, posing significant treatment challenges.
  • Successful treatment was achieved through a comprehensive multiple drug therapy approach.

Implications:

  • This case underscores the importance of considering rare and resistant TB strains in pediatric populations.
  • Effective management of multidrug-resistant tuberculosis requires tailored, combination therapies.
  • Understanding drug resistance patterns, including in immigrant communities, is crucial for public health strategies.

Keywords:
Mycobacterium africanumtuberculosis, Mycobacterium africanum

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