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A kinetic analysis of platelet monoamine oxidase activity in patients with panic attacks
T R Norman1, A Acevedo, I M McIntyre
1Department of Psychiatry, University of Melbourne, Austin Hospital, Heidelberg, Vic., Australia.
Journal of Affective Disorders
|September 1, 1988
Abstract:
A kinetic analysis of platelet monoamine oxidase (MAO) was performed in 22 patients with panic disorder and 14 normal controls, using tyramine as a substrate. Patients and controls did not differ significantly for either Km or Vmax, when same sex contrasts were carried out. The results do not support some studies that have shown elevated MAO activity in patients with panic attacks. The reasons for the discrepancies between previous studies and the present one are explored.