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Updated: Aug 18, 2026

An Ex vivo Model to Study Hormone Action in the Human Breast
Published on: January 8, 2015
Hormonal profile in benign breast disease. Endocrine status of cyclical mastalgia patients
E Parlati1, A Travaglini, I Liberale
1Istituto di Clinica Ostetrica e Ginecologica, Università Cattolica del S. Cuore, Roma, Italy.
Abstract:
Plasma levels of prolactin, before and after TRH stimulation, progesterone, estradiol, sex-hormone-binding-globulin, androstenedione, testosterone and dehydroepiandrosterone-sulphate were determined in a group of women with benign breast disease and in control group, in order to correlate a possible hormonal disorder to breast pathology. The hormonal pattern in the patients with benign breast disease was characterized by an increased responsiveness of lactotrophes to TRH stimulation and by higher levels of sex hormone binding globulin, probably sustained by an underlying hyperestrogenism.
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