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Posttraumatic headache (PTH) is a common and disabling symptom following traumatic brain injury (TBI). This review identifies key questions about PTH

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Area of Science:

  • Neurology
  • Traumatic Brain Injury Research
  • Headache Medicine

Background:

  • Headache is the most common acute symptom after traumatic brain injury (TBI).
  • Posttraumatic headache (PTH) is a persistent and disabling symptom, affecting 18-58% of TBI patients at 1 year.
  • PTH is a predictor of overall outcome after concussion and carries significant socioeconomic costs.

Purpose of the Study:

  • To identify key unanswered questions regarding the clinical characteristics of posttraumatic headache (PTH).
  • To explore the basic pathophysiological mechanisms underlying PTH after TBI.
  • To review and suggest optimal management strategies and novel therapeutic targets for PTH.

Main Methods:

  • Literature review focusing on clinical characteristics, mechanisms, and management of PTH.
  • Discussion of phenotypic features of PTH.
  • Exploration of pathophysiological mechanisms of TBI and potential overlaps with primary headache disorders.

Main Results:

  • PTH is a prevalent and disabling condition following TBI.
  • Fundamental questions regarding PTH's clinical presentation, mechanisms, and treatment remain unanswered.
  • Potential overlaps exist between TBI pathophysiology and mechanisms of migraine and other primary headaches.

Conclusions:

  • Further research is crucial to address fundamental questions about PTH.
  • Understanding PTH mechanisms may reveal novel therapeutic targets.
  • Developing effective therapies for PTH requires advancing the understanding of the disorder.