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Updated: Feb 10, 2026

Dissection of the Endolymphatic Sac from Mice
Published on: March 29, 2021
[Long-term results of endolymphatic sac mastoid drainage for Ménière disease]
Abstract:
Objective:To investigate the long-term efficacy of endolymphatic sac mastoid drainage for Ménière disease.Method:Data from 26 patients diagnosed with MD strictly meeting the criteria issued by " Guideline of diagnosis and treatment of Meniere disease(2017)" from 2006 to 2015 were analyzed in this study.Endolymphatic sac mastoid shunt surgery was performed for each patient.The therapeutic effect was evaluated against the " Guideline of diagnosis and treatment of Meniere disease(2017)".Vertigo control and auditory function were measured after at least two years follow up.Result:In 26 cases,16 cases were male and 10 cases were femaleThe age ranged from 24 to 71 years old,with an average of 52.04 years.The disease duration ranged from 1 to 32 years.22 cases were diagnosed as unilateral Ménière disease,and bilateral involvement was identified in 4 cases,thus a total of 30 ears were included.According to the preoperative staging of hearing,there were 0 cases in stage one,5 cases in stage two,16 in stage three and 9 cases in stage four.15 cases(57.7%)achieved class A vertigo conrol(complete control),9 cases(34.6%)class B(substantial control)and 2 cases(7.7%)class D(no control).The severity of vertigo and its impact on daily life were improved in 24 cases(92.3%)with a score of 0 point,and 2 cases(7.7%)scored 2 points.Post-operative hearing was improved in 3 cases(11.5%),unchanged in 16 cases(61.6%)and worsened in 7 cases(26.9%).After operation,tinnitus disappeared in 5 cases(19.2%),reduced in 13 case(50%)and unchanged in 8 cases(30.8%).Conclusion:Endolymphatic sac mastoid drainage was an effective and safe management for intractable Ménière disease patients with pre-operative residual hearing.The occurrence of complication was unsual.The patients who are in stage four could gain benifits from the surgery.
Insights
Endolymphatic sac mastoid drainage offers effective vertigo control for Ménière disease patients. This safe surgical option improved daily life for 92.3% of patients, with benefits also seen in those with advanced disease.
Area of Science:
- Otolaryngology
- Neurosurgery
- Medical Device Technology
Background:
- Ménière disease is a chronic inner ear disorder.
- Intractable symptoms significantly impact quality of life.
- Limited effective long-term treatment options exist.
Purpose of the Study:
- To evaluate the long-term efficacy and safety of endolymphatic sac mastoid drainage.
- To assess outcomes in patients with Ménière disease.
- To determine the impact on vertigo, hearing, and tinnitus.
Main Methods:
- Retrospective analysis of 26 Ménière disease patients (2006-2015).
- All patients underwent endolymphatic sac mastoid shunt surgery.
- Outcomes assessed using "Guideline of diagnosis and treatment of Meniere disease(2017)" after a minimum two-year follow-up.
Main Results:
- Complete or substantial vertigo control achieved in 92.3% of patients.
- 92.3% of patients reported improvement in vertigo severity and daily life impact.
- Post-operative hearing improved in 11.5%, remained unchanged in 61.6%, and worsened in 26.9%.
- Tinnitus improved in 69.2% of cases.
Conclusions:
- Endolymphatic sac mastoid drainage is an effective and safe treatment for intractable Ménière disease.
- The procedure benefits patients with pre-operative residual hearing.
- Stage four patients can experience significant benefits from this surgical intervention.
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