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Transabdominal chorionic villus sampling: analysis of 350 consecutive cases
L Bovicelli1, N Rizzo, V Montacuti
1Second Department of Obstetrics and Gynecology, University School of Medicine, Bologna, Italy.
Prenatal Diagnosis
|September 1, 1988
Summary
Transabdominal chorionic villus sampling (CVS) is a safe and effective first-trimester genetic testing method. This study in 350 patients demonstrates its feasibility and positive outcomes for fetal health.
Area of Science:
- Medical Science
- Genetics
- Obstetrics
Background:
- First-trimester genetic testing is crucial for prenatal diagnosis.
- Chorionic villus sampling (CVS) offers early genetic information.
- Transabdominal CVS is a common method for obtaining samples.
Purpose of the Study:
- To evaluate the feasibility and effectiveness of transabdominal chorionic villus sampling (CVS).
- To assess the outcomes of pregnancies undergoing transabdominal CVS.
- To determine the safety profile of the procedure.
Main Methods:
- A series of 350 patients underwent transabdominal CVS.
- The procedure utilized two ultrasound-guided needles and a suction pump.
- Most procedures were performed between 9 and 13 weeks of gestation.
Main Results:
- 169 delivered fetuses were alive and well.
- 153 pregnancies are currently in progress.
- There were 9 spontaneous abortions and 1 late fetal loss post-procedure.
Conclusions:
- Transabdominal CVS is a feasible and effective technique for first-trimester genetic diagnosis.
- The procedure demonstrates a favorable safety profile with positive pregnancy outcomes.
- Ultrasound-guided transabdominal biopsy is a reliable method for chorionic villus sampling.