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Hemostasis biomarkers in multiple sclerosis

N Ziliotto1,2, F Bernardi1, D Jakimovski2

  • 1Department of Life Sciences and Biotechnology, University of Ferrara, Ferrara, Italy.

European Journal of Neurology
|May 15, 2018
PubMed
Abstract

Insights

This study found altered levels of hemostasis factors in multiple sclerosis (MS) patients, with lower ADAMTS13 and higher PAI-1 and TFPI. No association was found with disease severity or MRI outcomes.

Area of Science:

  • Neuroscience
  • Hematology
  • Immunology

Background:

  • Multiple Sclerosis (MS) is a chronic inflammatory disease of the central nervous system.
  • Hemostasis, the process of stopping bleeding, involves complex interactions of factors and inhibitors.
  • Alterations in hemostasis may play a role in MS pathogenesis and progression.

Purpose of the Study:

  • To investigate plasma levels of hemostasis components in MS patients.
  • To explore associations between these levels and clinical/MRI outcomes in MS.
  • To compare hemostasis profiles between MS subtypes and healthy individuals.

Main Methods:

  • Studied 138 MS patients (RR-MS and P-MS) and 42 healthy individuals (HI).
  • Assessed plasma levels of hemostasis factors (FXII) and inhibitors (TFPI, ADAMTS13, PAI-1, etc.) using Luminex assays and ELISA.
  • Performed 3T MRI and clinical examinations for all participants.

Main Results:

  • MS patients showed lower ADAMTS13 levels compared to HI (P=0.008).
  • MS patients with cerebral microbleeds had lower ADAMTS13 levels (P=0.034).
  • Higher PAI-1 (P=0.02) and TFPI (P=0.002) levels were observed in MS patients compared to HI, with TFPI elevated in progressive MS (P-MS) versus relapsing-remitting MS (RR-MS) (P=0.011).

Conclusions:

  • MS patients exhibit distinct hemostasis profiles, including decreased ADAMTS13 and increased PAI-1 and TFPI.
  • Lower ADAMTS13 in MS patients with cerebral microbleeds warrants further investigation.
  • No significant associations were found between hemostasis plasma levels and measures of disease severity or MRI outcomes.
Keywords:
MRIcerebral microbleedscoagulationcoagulation inhibitorsmultiple sclerosis

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