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Targeting the CD73-adenosine axis in immuno-oncology
David Allard1, Pavel Chrobak1, Bertrand Allard1
1Centre de Recherche du Centre, Hospitalier l'Université de Montréal (CRCHUM) et Institut du Cancer de Montréal, Montréal, QC, Canada; Faculté de Pharmacie de l'Université de Montréal, Montréal, QC, Canada.
Immunology Letters
|May 15, 2018
Summary
CD39 and CD73 enzymes break down ATP into adenosine, impacting immune homeostasis. Targeting this pathway, particularly CD73 and adenosine, shows promise for enhancing cancer immunotherapy and developing new treatments.
Area of Science:
- Immunology
- Biochemistry
- Oncology
Background:
- CD39 and CD73 are cell surface enzymes crucial for the extracellular purinergic pathway.
- They regulate extracellular ATP breakdown to adenosine, maintaining tissue and immune homeostasis.
Purpose of the Study:
- To review recent studies on the roles of CD73 and adenosine in cancer.
- To focus on cell-specific functions and discuss therapeutic strategies in immuno-oncology.
Main Methods:
- Literature review of the latest studies on CD73, adenosine, and cancer.
- Analysis of ongoing clinical trials for adenosine-targeting agents.
Main Results:
- Ectonucleotidases and adenosine receptors are emerging therapeutic targets in cancer immunotherapy.
- Early-phase clinical trials demonstrate promising results for adenosine-targeting agents.
Conclusions:
- Understanding cell-specific roles of CD73 and adenosine is key for effective immuno-oncology therapeutics.
- Further research is needed to decipher mechanisms-of-action, identify patient responders, and develop synergistic combinations.
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