Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Sample Size Calculation01:19

Sample Size Calculation

6.7K
Knowledge of the sample size is the first requirement to conduct random sampling or an experiment. The sample size is the total number of units, observations, or groups (in some cases) used to get the data to estimate a population parameter. As the name suggests, the sample size is that of the sample drawn from the population and differs from the population size.
The sample size for the given experiment or sampling effort is fundamental to any study design. Sample size decides the number of...
6.7K
Intracellular Signaling Cascades01:24

Intracellular Signaling Cascades

53.7K
Once a ligand binds to a receptor, the signal is transmitted through the membrane and into the cytoplasm. The continuation of a signal in this manner is called signal transduction. Signal transduction only occurs with cell-surface receptors, which cannot interact with most components of the cell, such as DNA. Only internal receptors can interact directly with DNA in the nucleus to initiate protein synthesis. When a ligand binds to its receptor, conformational changes occur that affect the...
53.7K
Rab Cascades01:25

Rab Cascades

3.6K
Rab GTPases act in a regulated cascade during membrane fusion, helping the lipid bilayers mix. The Rab family of proteins are active when bound to GTP, and inactive when bound to GDP. Hence, they act as guanine nucleotide-dependent molecular switches. Rab-GTP recognizes and binds to long or short-range tethering proteins to capture the target vesicle. These tethers coordinate with SNAREs on the vesicle and the target membrane to assemble the trans SNARE complex that locks the mixing bilayers.
3.6K
Protein Networks02:26

Protein Networks

4.6K
An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
4.6K
Amplifying Signals via Enzymatic Cascade01:22

Amplifying Signals via Enzymatic Cascade

18.6K
When a ligand binds to a cell-surface receptor, the receptor's intracellular domain changes shape, which may either activate its enzyme function or allow its binding to other molecules. The initial signal is amplified by most signal transduction pathways. This means that a single ligand molecule can activate multiple molecules of a downstream target. Proteins that relay a signal are most commonly phosphorylated at one or more sites, activating or inactivating the protein. Kinases catalyze...
18.6K
MAPK Signaling Cascades01:07

MAPK Signaling Cascades

8.5K
Mitogen-activated protein kinase, or MAPK pathway, activates three sequential kinases to regulate cellular responses such as proliferation, differentiation, survival, and apoptosis. The canonical MAPK pathway starts with a mitogen or growth factor binding to an RTK. The activated RTKs stimulate Ras, which recruits Raf or MAP3 Kinase (MAPKKK), the first kinase of the MAPK signaling cascade. Raf further phosphorylates and activates MEK or MAP2 Kinases (MAPKK), which in turn phosphorylates MAP...
8.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Sex differences in gene regulation and its impact on cancer incidence.

iScience·2026
Same author

How malicious AI swarms can threaten democracy.

Science (New York, N.Y.)·2026
Same author

Sex differences in gene regulation and its impact on cancer incidence.

bioRxiv : the preprint server for biology·2025
Same author

Supply-chain vulnerabilities in critical medicines: A persistent risk to pharmaceutical security.

Science (New York, N.Y.)·2025
Same author

US tariffs jeopardize medicine supply chains.

Science (New York, N.Y.)·2025
Same author

The nonlinear economy: How resource constraints lead to business cycles.

Chaos (Woodbury, N.Y.)·2025
Same journal

Erratum: Low-dimensional model for adaptive networks of spiking neurons [Phys. Rev. E 111, 014422 (2025)].

Physical review. E·2026
Same journal

Disentangling the effects of many-body forces on depletion interactions.

Physical review. E·2026
Same journal

Charge transport and mode transition in dual-energy electron beam diodes.

Physical review. E·2026
Same journal

Optimization of multisite reactions in complex compartmentalized media.

Physical review. E·2026
Same journal

Origin of geometric cohesion in nonconvex granular materials: Interplay between interdigitation and rotational constraints enhancing frictional stability.

Physical review. E·2026
Same journal

Interaction of walkers with a standing Faraday wave.

Physical review. E·2026
See all related articles

Related Experiment Video

Updated: Feb 10, 2026

Author Spotlight: Advancing Biotherapeutic Mass Calculation by Introducing mAbScale, a Python-Based Desktop Application
04:24

Author Spotlight: Advancing Biotherapeutic Mass Calculation by Introducing mAbScale, a Python-Based Desktop Application

Published on: June 16, 2023

2.3K

Framework for cascade size calculations on random networks.

Rebekka Burkholz1, Frank Schweitzer1

  • 1ETH Zurich, Chair of Systems Design Weinbergstrasse 56/58, 8092 Zurich, Switzerland.

Physical Review. E
|May 16, 2018
PubMed
Summary
This summary is machine-generated.

We developed a new framework to precisely calculate cascade size evolution in large random networks. This method accurately models complex network dynamics beyond traditional approximations, offering insights into historical dependencies.

More Related Videos

Analyzing the Size, Shape, and Directionality of Networks of Coupled Astrocytes
10:10

Analyzing the Size, Shape, and Directionality of Networks of Coupled Astrocytes

Published on: October 4, 2018

9.4K
Author Spotlight: Tackling Challenges in Synthetic Cell Engineering
10:56

Author Spotlight: Tackling Challenges in Synthetic Cell Engineering

Published on: April 12, 2024

1.7K

Related Experiment Videos

Last Updated: Feb 10, 2026

Author Spotlight: Advancing Biotherapeutic Mass Calculation by Introducing mAbScale, a Python-Based Desktop Application
04:24

Author Spotlight: Advancing Biotherapeutic Mass Calculation by Introducing mAbScale, a Python-Based Desktop Application

Published on: June 16, 2023

2.3K
Analyzing the Size, Shape, and Directionality of Networks of Coupled Astrocytes
10:10

Analyzing the Size, Shape, and Directionality of Networks of Coupled Astrocytes

Published on: October 4, 2018

9.4K
Author Spotlight: Tackling Challenges in Synthetic Cell Engineering
10:56

Author Spotlight: Tackling Challenges in Synthetic Cell Engineering

Published on: April 12, 2024

1.7K

Area of Science:

  • Complex Systems and Network Science
  • Statistical Physics
  • Computational Social Science

Background:

  • Cascade models are crucial for understanding phenomena like information diffusion and system failures.
  • Existing methods, such as branching process approximations, have limitations in capturing complex cascade dynamics.
  • Previous approaches struggled with networks exhibiting arbitrary degree distributions, correlations, and continuous or history-dependent cascade variables.

Purpose of the Study:

  • To introduce a novel, exact framework for calculating cascade size evolution in random network ensembles.
  • To extend the analysis beyond traditional branching process approximations.
  • To accommodate complex network structures and cascade dynamics, including history-dependent and continuous quantities.

Main Methods:

  • Developed an iterative probability distribution update method, shifting focus from branching processes.
  • The framework is exact in the limit of infinite network size.
  • Applies to network ensembles with arbitrary degree distributions, degree-degree correlations, and threshold distributions.

Main Results:

  • The framework successfully calculates cascade size evolution for a broad class of cascade models.
  • Demonstrated applicability to constant load models, which encompass many analytically tractable cascade models.
  • Successfully analyzed a fiber bundle model, previously intractable with branching process approximations, revealing its full cascade dynamics.

Conclusions:

  • The proposed framework offers an exact and versatile method for analyzing cascade dynamics in complex networks.
  • It overcomes limitations of prior approximation techniques, enabling the study of more realistic and complex systems.
  • The method's ability to capture historical dependencies and continuous quantities opens new avenues for research in network science and related fields.