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Gender-based differences in hemostatic responses.

Omer Iqbal1, Nasir Sadeghi2, Fadi Bakhos2

  • 1Department of Pathology, Loyola University Medical Center, 2160 S. First Avenue, Maywood, IL 60153, USA. oiqbal@lumc.edu.

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|May 16, 2018
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Summary
This summary is machine-generated.

Women exhibit distinct hemostatic responses to anticoagulant medications like rivaroxaban and enoxaparin. These gender-based differences in coagulation assays highlight the need for personalized drug dosing to prevent adverse events.

Keywords:
anticoagulantsfibrinokineticsgenderhemostasisthrombosis

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Area of Science:

  • Cardiovascular Medicine
  • Hematology
  • Pharmacology

Background:

  • Cardiovascular diseases (CVDs) pose a significant mortality risk for women, necessitating gender-specific research.
  • Hemostatic responses to anticoagulant therapies may differ between sexes, impacting treatment efficacy and safety.

Purpose of the Study:

  • To investigate gender-based differences in hemostatic responses to common anticoagulant drugs.
  • To evaluate the impact of rivaroxaban and enoxaparin on coagulation parameters in males and females.

Main Methods:

  • Healthy male and female volunteers (n=10 each) participated in the study.
  • Citrated whole blood was treated with rivaroxaban (0.3 µg/ml) and enoxaparin (5 µg/ml).
  • Various hemostasis assays, including activated partial thromboplastin time and Heptest®, were performed.

Main Results:

  • Significant gender-based differences were observed in whole blood and plasma assays, including Heptest® and domain-dimer.
  • Females demonstrated faster fibrin formation compared to males.
  • Specific assays like von Willebrand factor multimers also revealed gender-related variations.

Conclusions:

  • The study confirms gender-based differences in hemostatic responses to anticoagulants.
  • Individualized adjustment of anticoagulant dosages is crucial to mitigate risks of bleeding or thrombosis in women.