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Updated: Feb 10, 2026

Generation of Comprehensive Thoracic Oncology Database - Tool for Translational Research
11:18

Generation of Comprehensive Thoracic Oncology Database - Tool for Translational Research

Published on: January 22, 2011

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Clinical trials for precision oncology using next-generation sequencing

Richard Simon1, Eric Polley2

  • 1Biometric Research Branch, National Cancer Institute, 9609 Medical Center Drive, Room 5W110, MSC 9735, Bethesda, MD 20892, USA. rsimon@nih.gov .

Personalized Medicine
|May 16, 2018
PubMed

Insights

Genomic heterogeneity in cancer impacts drug development. Understanding tumor genomics and pathway crosstalk is crucial for effective cancer therapeutics and personalized diagnostics.

Area of Science:

  • Oncology
  • Genomics
  • Molecular Diagnostics

Background:

  • Human cancers exhibit significant genomic heterogeneity, influencing therapeutic development and diagnostic strategies.
  • Targeted cancer therapies and companion diagnostics are increasingly focused on specific tumor genetic alterations.
  • The oncology landscape is shifting towards stratified approaches, including enrichment Phase III trials.

Purpose of the Study:

  • To review the challenges and ongoing clinical studies in translating tumor genomics into clinical oncology practice.
  • To highlight the need for a deeper understanding of signaling pathway crosstalk for improved cancer treatment outcomes.
  • To emphasize the potential of early-phase clinical trials with comprehensive genomic characterization for treatment matching.

Main Methods:

  • Review of current challenges in clinical genomics implementation.
  • Analysis of clinical studies focused on translating genomic data into oncology.
  • Discussion of strategies for effective therapeutic matching based on genomic alterations.

Main Results:

  • Single-agent targeted therapies for metastatic disease offer limited patient benefit.
  • Substantial gains necessitate understanding pathway crosstalk, drug combinations, and early-stage treatment.
  • Early-phase trials with genome-wide tumor characterization are vital for generating data on therapeutic matching.

Conclusions:

  • Translating tumor genomics into clinical oncology faces practical hurdles.
  • Effective cancer treatment requires a move beyond single-agent therapies to combination strategies informed by comprehensive genomic data.
  • Ongoing clinical studies aim to overcome these challenges and integrate genomics into routine cancer care.
Keywords:
cancer biomarkercancer clinical trialnext-generation sequencingpersonalized medicineprecision medicine

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