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Related Experiment Video

Updated: Feb 10, 2026

The Mouse Round-window Approach for Ototoxic Agent Delivery: A Rapid and Reliable Technique for Inducing Cochlear Cell Degeneration
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Alginate Ototoxicity in the Mouse Model.

Sameer A Alvi1, Jennifer Nelson-Brantley2, Hinrich Staecker1,2

  • 11 Department of Otolaryngology, University of Kansas Medical Center, Kansas City, Kansas, USA.

Otolaryngology--Head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery
|May 16, 2018
PubMed
Summary

Alginate applied to the mouse round window did not cause hearing loss or vestibular issues. Histologic examination showed no damage, suggesting alginate is not ototoxic in this model.

Keywords:
alginatemiddle ear packingototoxicityresorbable material

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Area of Science:

  • Ototoxicity research
  • Auditory neuroscience
  • Medical biomaterials

Background:

  • Alginate is a biomaterial with potential applications in otologic surgery.
  • Its safety and ototoxicity profile require thorough investigation.

Purpose of the Study:

  • To evaluate the ototoxic potential of alginate when applied to the round window membrane in a mouse model.

Main Methods:

  • Prospective animal study involving 5 adult mice.
  • Bullostomy and alginate application to the round window niche.
  • Auditory brainstem response (ABR) testing at baseline and post-procedure (days 5, 14, 30).
  • Histologic examination of cochleae post-sacrifice.

Main Results:

  • No significant increase in ABR thresholds observed at any time point post-alginate exposure compared to baseline.
  • No behavioral signs of vestibular dysfunction were noted.
  • Histologic analysis revealed no evidence of cochlear damage.

Conclusions:

  • Alginate exposure to the round window does not appear to cause significant ototoxicity in the mouse model.
  • Further clinical studies are warranted to confirm safety in human middle ear applications.